HCSGD entry for EGLN1
1. General information
| Official gene symbol | EGLN1 |
|---|---|
| Entrez ID | 54583 |
| Gene full name | egl nine homolog 1 (C. elegans) |
| Other gene symbols | C1orf12 ECYT3 HIF-PH2 HIFPH2 HPH-2 HPH2 PHD2 SM20 ZMYND6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IDA | biological_process |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0018401 | Peptidyl-proline hydroxylation to 4-hydroxy-L-proline | IDA | biological_process |
| GO:0019899 | Enzyme binding | ISS | molecular_function |
| GO:0030821 | Negative regulation of cAMP catabolic process | ISS | biological_process |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
| GO:0031543 | Peptidyl-proline dioxygenase activity | TAS | molecular_function |
| GO:0031545 | Peptidyl-proline 4-dioxygenase activity | IDA | molecular_function |
| GO:0032364 | Oxygen homeostasis | IDA | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0045765 | Regulation of angiogenesis | ISS | biological_process |
| GO:0051344 | Negative regulation of cyclic-nucleotide phosphodiesterase activity | ISS | biological_process |
| GO:0055008 | Cardiac muscle tissue morphogenesis | IEA | biological_process |
| GO:0060347 | Heart trabecula formation | IEA | biological_process |
| GO:0060412 | Ventricular septum morphogenesis | IEA | biological_process |
| GO:0060711 | Labyrinthine layer development | IEA | biological_process |
| GO:0061418 | Regulation of transcription from RNA polymerase II promoter in response to hypoxia | TAS | biological_process |
| GO:0071456 | Cellular response to hypoxia | TAS | biological_process |
| GO:0071731 | Response to nitric oxide | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0715232476 | 0.4395547928 | 0.5706466808 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4460102873 |
| GSE13712_SHEAR | Up | 0.4586971912 |
| GSE13712_STATIC | Up | 0.2038249399 |
| GSE19018 | Up | 0.7613071452 |
| GSE19899_A1 | Up | 0.2029025016 |
| GSE19899_A2 | Up | 1.0177552642 |
| PubMed_21979375_A1 | Up | 0.3095452979 |
| PubMed_21979375_A2 | Up | 0.8040902707 |
| GSE35957 | Down | -0.4561257305 |
| GSE36640 | Down | -0.3577249135 |
| GSE54402 | Up | 0.1351500193 |
| GSE9593 | Up | 0.0865339941 |
| GSE43922 | Up | 0.0393039226 |
| GSE24585 | Down | -0.0715266995 |
| GSE37065 | Up | 0.0603624816 |
| GSE28863_A1 | Up | 0.1135722372 |
| GSE28863_A2 | Down | -0.2289296563 |
| GSE28863_A3 | Down | -0.3618580029 |
| GSE28863_A4 | Down | -0.3082373221 |
| GSE48662 | Up | 0.4126141343 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
| FG-4592 | DB04847 | - |
| N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE | DB07112 | - |
| N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE | DB08687 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016815 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038498 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21746877 | Additionally, we found that cyclin E deregulation in mammary acini decreases, in an E2F-independent manner, expression of the EGLN1 prolyl hydroxylase that regulates HIF-1alpha degradation within the VHL ubiquitin ligase pathway |
| 16161047 | Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1 |
| 16161047 | Introduction of wild-type EGLN1 into endometrial cancer cell lines (HHUA, Ishikawa and HWCA), that carry EGLN1 gene mutations induced senescence |
| 16161047 | Thus, EGLN1 can be considered as a candidate tumor suppressor on chr |
| 16161047 | These results also suggested the availability of negative regulation of HIF-1 signals for uterine cancer treatment, especially for uterine sarcomas that have worse prognosis and show a high frequency of EGLN1 gene abnormality |
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