HCSGD entry for ING3
1. General information
| Official gene symbol | ING3 |
|---|---|
| Entrez ID | 54556 |
| Gene full name | inhibitor of growth family, member 3 |
| Other gene symbols | Eaf4 ING2 MEAF4 p47ING3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004402 | Histone acetyltransferase activity | IDA | molecular_function |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0032777 | Piccolo NuA4 histone acetyltransferase complex | IDA | cellular_component |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0035267 | NuA4 histone acetyltransferase complex | IDA | cellular_component |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043967 | Histone H4 acetylation | IDA | biological_process |
| GO:0043968 | Histone H2A acetylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9878718248 | 0.0188992705 | 0.9999902473 | 0.2697582656 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2763699613 |
| GSE13712_SHEAR | Down | -0.0642922957 |
| GSE13712_STATIC | Up | 0.0511967206 |
| GSE19018 | Down | -0.2705628141 |
| GSE19899_A1 | Down | -0.2858311421 |
| GSE19899_A2 | Down | -0.8808701041 |
| PubMed_21979375_A1 | Down | -0.2585544347 |
| PubMed_21979375_A2 | Down | -0.6885018672 |
| GSE35957 | Down | -0.0265064443 |
| GSE36640 | Down | -0.6408696632 |
| GSE54402 | Down | -0.2492602983 |
| GSE9593 | Down | -0.2773832594 |
| GSE43922 | Down | -0.3531594906 |
| GSE24585 | Down | -0.1603614519 |
| GSE37065 | Up | 0.2843179506 |
| GSE28863_A1 | Up | 0.0035474471 |
| GSE28863_A2 | Up | 0.0109126251 |
| GSE28863_A3 | Down | -0.6179282943 |
| GSE28863_A4 | Down | -0.1449128736 |
| GSE48662 | Down | -0.1727111193 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-378a-5p | MIMAT0000731 | MIRT043992 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21767350 | While ING1, ING2 and ING3 proteins are stable components of the mSIN3a-HDAC complexes, the association of ING1, ING4 and ING5 with HAT protein complexes was also reported |
| 16520380 | We found that ING3 expression was rapidly induced by UV irradiation at both mRNA and protein levels |
| 16520380 | Using the stable clones of melanoma cells overexpressing ING3, we showed that overexpression of ING3 significantly promoted UV-induced apoptosis |
| 16520380 | Furthermore, ING3 did not affect the expression of mitochondrial proteins but increased the cleavage of Bid and caspases-8, -9, and -3 |
| 16520380 | Knock down of ING3 decreased UV-induced apoptosis remarkably |
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