HCSGD entry for GNL3L
1. General information
| Official gene symbol | GNL3L |
|---|---|
| Entrez ID | 54552 |
| Gene full name | guanine nucleotide binding protein-like 3 (nucleolar)-like |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006184 | GTP catabolic process | IBA | biological_process |
| GO:0008152 | Metabolic process | IBA | biological_process |
| GO:0042254 | Ribosome biogenesis | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3840142624 | 0.1404261502 | 0.9999902473 | 0.7210983048 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1014282737 |
| GSE13712_SHEAR | Down | -0.1826925649 |
| GSE13712_STATIC | Up | 0.0756975955 |
| GSE19018 | Down | -0.1038278930 |
| GSE19899_A1 | Up | 0.1171093251 |
| GSE19899_A2 | Up | 0.7210335720 |
| PubMed_21979375_A1 | Down | -0.2856578188 |
| PubMed_21979375_A2 | Down | -0.0068977644 |
| GSE35957 | Up | 0.1009174481 |
| GSE36640 | Down | -0.2497846913 |
| GSE54402 | Up | 0.3891906434 |
| GSE9593 | Up | 0.0300676520 |
| GSE43922 | Up | 0.2800925688 |
| GSE24585 | Down | -1.0065234622 |
| GSE37065 | Down | -0.3455015940 |
| GSE28863_A1 | Down | -0.5004082590 |
| GSE28863_A2 | Down | -0.1013758310 |
| GSE28863_A3 | Up | 0.1808178373 |
| GSE28863_A4 | Down | -0.1500883773 |
| GSE48662 | Up | 0.1617925011 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001463 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020962 | Proteomics | Functional MTI (Weak) | 20584899 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021788 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023356 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046484 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19501670 | A genome-wide search reveals that nucleostemin and its closest homologue, GNL3L, only emerge as separate genes in vertebrates and possess conserved protein sequences as evolution proceeded to the Mammalia |
| 19501670 | The invertebrate orthologue of nucleostemin and GNL3L resembles GNL3L more than it does nucleostemin in function, raising the idea that nucleostemin acquires new properties while GNL3L inherits an evolutionarily fixed role, and that the birth of nucleostemin may signify the appearance of new functional features in the vertebrate lineage |
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