HCSGD entry for SMOX
1. General information
| Official gene symbol | SMOX |
|---|---|
| Entrez ID | 54498 |
| Gene full name | spermine oxidase |
| Other gene symbols | C20orf16 PAO PAO-1 PAOH1 SMO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006595 | Polyamine metabolic process | TAS | biological_process |
| GO:0006596 | Polyamine biosynthetic process | TAS | biological_process |
| GO:0006598 | Polyamine catabolic process | IDA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046208 | Spermine catabolic process | IDA IEA | biological_process |
| GO:0046592 | Polyamine oxidase activity | IDA | molecular_function |
| GO:0052894 | Norspermine:oxygen oxidoreductase activity | IEA | molecular_function |
| GO:0052895 | N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity | IEA | molecular_function |
| GO:0052901 | Spermine:oxygen oxidoreductase (spermidine-forming) activity | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0257096615 | 0.4868848258 | 0.3757379234 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0807570210 |
| GSE13712_SHEAR | Up | 0.1050340617 |
| GSE13712_STATIC | Up | 0.0997817354 |
| GSE19018 | Up | 0.0686571592 |
| GSE19899_A1 | Up | 0.4369539976 |
| GSE19899_A2 | Up | 0.8441225963 |
| PubMed_21979375_A1 | Up | 2.5593039367 |
| PubMed_21979375_A2 | Up | 0.6510290721 |
| GSE35957 | Down | -1.0073155441 |
| GSE36640 | Up | 0.0639252129 |
| GSE54402 | Up | 0.1494874549 |
| GSE9593 | Down | -0.4464939880 |
| GSE43922 | Up | 1.5657984935 |
| GSE24585 | Down | -0.2563651255 |
| GSE37065 | Up | 0.4623832571 |
| GSE28863_A1 | Down | -0.2177226363 |
| GSE28863_A2 | Down | -0.0995825758 |
| GSE28863_A3 | Up | 0.0882211582 |
| GSE28863_A4 | Up | 0.0310570676 |
| GSE48662 | Down | -0.0661749002 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Spermine | DB00127 | NUTR00055 | EXPT02947 | DB02564 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040277 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-324-5p | MIMAT0000761 | 1 | hsa-miR-324-5p | {Western blot} | {overexpression by miRNA mimics tranfection} | 18756266 | |
| hsa-miR-125b-5p | MIMAT0000423 | 1 | hsa-miR-125b | {Western blot} | {overexpression by miRNA mimics tranfection} | 18756266 | |
| hsa-miR-326 | MIMAT0000756 | 1 | hsa-miR-326 | {Western blot} | {overexpression by miRNA mimics tranfection} | 18756266 | |
| hsa-let-7a-5p | MIMAT0000062 | NA | hsa-let-7a | 19939273 | |||
| hsa-let-7d-5p | MIMAT0000065 | NA | hsa-let-7d | 19939273 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
