HCSGD entry for PRMT7

1. General information

Official gene symbolPRMT7
Entrez ID54496
Gene full nameprotein arginine methyltransferase 7
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000387Spliceosomal snRNP assemblyIMPbiological_process
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006349Regulation of gene expression by genetic imprintingIEA ISSbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0008276Protein methyltransferase activityIEAmolecular_function
GO:0008469Histone-arginine N-methyltransferase activityIDAmolecular_function
GO:0008757S-adenosylmethionine-dependent methyltransferase activityIDAmolecular_function
GO:0016277[myelin basic protein]-arginine N-methyltransferase activityIDAmolecular_function
GO:0016571Histone methylationIDAbiological_process
GO:0018216Peptidyl-arginine methylationIDA IMPbiological_process
GO:0019918Peptidyl-arginine methylation, to symmetrical-dimethyl arginineIDA IMPbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0034969Histone arginine methylationISSbiological_process
GO:0035241Protein-arginine omega-N monomethyltransferase activityIDAmolecular_function
GO:0035243Protein-arginine omega-N symmetric methyltransferase activityIDA IMPmolecular_function
GO:0035246Peptidyl-arginine N-methylationIDA IMP ISSbiological_process
GO:0035247Peptidyl-arginine omega-N-methylationIDAbiological_process
GO:0042393Histone bindingICmolecular_function
GO:0043021Ribonucleoprotein complex bindingIPImolecular_function
GO:0043046DNA methylation involved in gamete generationIEA ISSbiological_process
GO:0043393Regulation of protein bindingICbiological_process
GO:0044020Histone methyltransferase activity (H4-R3 specific)IEA ISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59628185860.53023065230.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0007749259
GSE13712_SHEARUp0.2572467823
GSE13712_STATICUp0.0899574159
GSE19018Down-0.0719835943
GSE19899_A1Down-0.0776297674
GSE19899_A2Down-0.2101031966
PubMed_21979375_A1Up0.6099388486
PubMed_21979375_A2Up0.6567165299
GSE35957Down-0.1330832697
GSE36640Up0.0019504166
GSE54402Up0.0361038080
GSE9593Down-0.3528761717
GSE43922Up0.0574142911
GSE24585Down-0.3742051935
GSE37065Down-0.0693554215
GSE28863_A1Up0.0551002259
GSE28863_A2Down-0.0037649076
GSE28863_A3Down-0.3487440291
GSE28863_A4Up0.0175206344
GSE48662Up0.1170693077

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT042041CLASHFunctional MTI (Weak)23622248
hsa-miR-30b-5pMIMAT0000420MIRT046164CLASHFunctional MTI (Weak)23622248
hsa-miR-10b-5pMIMAT0000254MIRT047476CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26854227PRMT7 Preserves Satellite Cell Regenerative Capacity
26854227Here, we report that whole-body protein arginine methyltransferase PRMT7(-/-) adult mice and mice conditionally lacking PRMT7 in satellite cells using Pax7-CreERT2 both display a significant reduction in satellite cell function, leading to defects in regenerative capacity upon muscle injury
26854227We show that PRMT7 is preferentially expressed in activated satellite cells and, interestingly, PRMT7-deficient satellite cells undergo cell-cycle arrest and premature cellular senescence
26854227Our findings define PRMT7 as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity
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