HCSGD entry for TOLLIP
1. General information
| Official gene symbol | TOLLIP |
|---|---|
| Entrez ID | 54472 |
| Gene full name | toll interacting protein |
| Other gene symbols | IL-1RAcPIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004871 | Signal transducer activity | NAS | molecular_function |
| GO:0005150 | Interleukin-1, Type I receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IC | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006954 | Inflammatory response | NAS | biological_process |
| GO:0007165 | Signal transduction | IPI | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0016310 | Phosphorylation | IDA | biological_process |
| GO:0016604 | Nuclear body | IEA | cellular_component |
| GO:0019900 | Kinase binding | IPI | molecular_function |
| GO:0031624 | Ubiquitin conjugating enzyme binding | IEA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0032183 | SUMO binding | IEA | molecular_function |
| GO:0033235 | Positive regulation of protein sumoylation | IEA | biological_process |
| GO:0035325 | Toll-like receptor binding | IPI | molecular_function |
| GO:0035556 | Intracellular signal transduction | NAS | biological_process |
| GO:0045087 | Innate immune response | IEA | biological_process |
| GO:0045092 | Interleukin-18 receptor complex | NAS | cellular_component |
| GO:0045321 | Leukocyte activation | NAS | biological_process |
| GO:0045323 | Interleukin-1 receptor complex | NAS | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0279529501 | 0.9850047187 | 0.3872366316 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2389410847 |
| GSE13712_SHEAR | Up | 0.2433879191 |
| GSE13712_STATIC | Down | -0.0058516070 |
| GSE19018 | Down | -0.1489667373 |
| GSE19899_A1 | Up | 0.1332940100 |
| GSE19899_A2 | Up | 0.9578969896 |
| PubMed_21979375_A1 | Up | 0.2881766573 |
| PubMed_21979375_A2 | Up | 0.9893931621 |
| GSE35957 | Up | 0.0533402309 |
| GSE36640 | Up | 0.4539223051 |
| GSE54402 | Up | 0.3010590654 |
| GSE9593 | Up | 0.6910099209 |
| GSE43922 | Up | 0.2662424021 |
| GSE24585 | Up | 0.0337266493 |
| GSE37065 | Down | -0.3195121407 |
| GSE28863_A1 | Up | 0.1977580447 |
| GSE28863_A2 | Up | 0.4514270594 |
| GSE28863_A3 | Down | -0.0038310338 |
| GSE28863_A4 | Up | 0.0558660984 |
| GSE48662 | Up | 0.0233562054 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020158 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028044 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041248 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27812125 | Genes-toll-interacting protein (TOLLIP), mitogen-activated protein kinase 9 (MAPK9), interleukin-1beta (IL-1beta), interleukin-8 (IL-8), and chemokine (C-X-C motif) ligand 1 (CXCL1)-related to these two pathways were validated using western blotting |
| 27812125 | Furthermore, expression of TOLLIP, a regulator of TLR signaling pathway, decreased with cellular aging as judged by changes in its expression through multiple passages |
| 27812125 | TOLLIP expression was downregulated in ALS cells under conditions of inflammation induced by lipopolysaccharide |
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