HCSGD entry for POR

1. General information

Official gene symbolPOR
Entrez ID5447
Gene full nameP450 (cytochrome) oxidoreductase
Other gene symbolsCPR CYPOR P450R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003420Regulation of growth plate cartilage chondrocyte proliferationIEAbiological_process
GO:0003958NADPH-hemoprotein reductase activityIBA IDA IEA TASmolecular_function
GO:0004128Cytochrome-b5 reductase activity, acting on NAD(P)HIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolIBAcellular_component
GO:0007584Response to nutrientIEAbiological_process
GO:0008941Nitric oxide dioxygenase activityIEAmolecular_function
GO:0009055Electron carrier activityIEAmolecular_function
GO:0009437Carnitine metabolic processIEAbiological_process
GO:0009812Flavonoid metabolic processIEAbiological_process
GO:0010181FMN bindingIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016491Oxidoreductase activityIBA IEAmolecular_function
GO:0016709Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenIBAmolecular_function
GO:0016787Hydrolase activityIEAmolecular_function
GO:0018393Internal peptidyl-lysine acetylationIEAbiological_process
GO:0019395Fatty acid oxidationIEAbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0032332Positive regulation of chondrocyte differentiationIEAbiological_process
GO:0032770Positive regulation of monooxygenase activityIDAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043602Nitrate catabolic processIEAbiological_process
GO:0045542Positive regulation of cholesterol biosynthetic processIEAbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIEAbiological_process
GO:0046210Nitric oxide catabolic processIEAbiological_process
GO:0047726Iron-cytochrome-c reductase activityIEAmolecular_function
GO:0050660Flavin adenine dinucleotide bindingIEAmolecular_function
GO:0050661NADP bindingIEAmolecular_function
GO:0055114Oxidation-reduction processIDA TASbiological_process
GO:0060192Negative regulation of lipase activityIEAbiological_process
GO:0070988DemethylationIEAbiological_process
GO:0071372Cellular response to follicle-stimulating hormone stimulusIEAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIEAbiological_process
GO:0090031Positive regulation of steroid hormone biosynthetic processIEAbiological_process
GO:0090346Cellular organofluorine metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02190493520.91391017820.35505461251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3774237021
GSE13712_SHEARDown-0.2594601608
GSE13712_STATICDown-0.0801555197
GSE19018Up0.0304589434
GSE19899_A1Up0.1570079100
GSE19899_A2Up1.0722893380
PubMed_21979375_A1Up0.3637975127
PubMed_21979375_A2Up2.1248833003
GSE35957Down-0.6191777721
GSE36640Down-0.0075934642
GSE54402Up0.3951889626
GSE9593Up0.3624569273
GSE43922Up0.4452313982
GSE24585Up0.1829344362
GSE37065Down-0.0260691180
GSE28863_A1Up0.0246005879
GSE28863_A2Up0.0438159416
GSE28863_A3Up0.1594686871
GSE28863_A4Down-0.0681457536
GSE48662Up0.3675839392

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Riboflavin MonophosphateDB03247 EXPT01458
2'-Monophosphoadenosine 5'-DiphosphoriboseDB03461 EXPT02293

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017903MicroarrayFunctional MTI (Weak)18185580
hsa-miR-671-5pMIMAT0003880MIRT039293CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049130CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.