HCSGD entry for PON3
1. General information
| Official gene symbol | PON3 |
|---|---|
| Entrez ID | 5446 |
| Gene full name | paraoxonase 3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004063 | Aryldialkylphosphatase activity | IEA | molecular_function |
| GO:0004064 | Arylesterase activity | IDA IEA NAS | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0009605 | Response to external stimulus | NAS | biological_process |
| GO:0010124 | Phenylacetate catabolic process | IEA | biological_process |
| GO:0018733 | 3,4-dihydrocoumarin hydrolase activity | IEA | molecular_function |
| GO:0019439 | Aromatic compound catabolic process | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0046226 | Coumarin catabolic process | IEA | biological_process |
| GO:0046395 | Carboxylic acid catabolic process | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0047856 | Dihydrocoumarin hydrolase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8843362714 | 0.2267473272 | 0.9999902473 | 0.9156514882 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1731740745 |
| GSE13712_SHEAR | Down | -0.1646922165 |
| GSE13712_STATIC | Down | -0.5852241039 |
| GSE19018 | Up | 0.3318552166 |
| GSE19899_A1 | Up | 0.0530807522 |
| GSE19899_A2 | Down | -0.1124222039 |
| PubMed_21979375_A1 | Down | -0.0572914984 |
| PubMed_21979375_A2 | Up | 0.0387635414 |
| GSE35957 | Down | -0.0811663180 |
| GSE36640 | Up | 0.1898744128 |
| GSE54402 | Down | -0.0534227474 |
| GSE9593 | Down | -0.5295657928 |
| GSE43922 | Up | 0.0162204722 |
| GSE24585 | Up | 0.0151941497 |
| GSE37065 | Down | -0.1835784515 |
| GSE28863_A1 | Down | -0.0571376381 |
| GSE28863_A2 | Up | 0.0229118393 |
| GSE28863_A3 | Up | 0.0494736536 |
| GSE28863_A4 | Up | 0.1009127808 |
| GSE48662 | Up | 0.0057567517 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017621 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21562236 | The expression of antioxidant defense genes, such as glutathione peroxidase-1, Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3), were significantly lower in the liver of HF/C pups than in C/C pups |
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