HCSGD entry for PON2
1. General information
| Official gene symbol | PON2 |
|---|---|
| Entrez ID | 5445 |
| Gene full name | paraoxonase 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004064 | Arylesterase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005764 | Lysosome | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0019439 | Aromatic compound catabolic process | IDA | biological_process |
| GO:0042802 | Identical protein binding | IDA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9686931348 | 0.0241818092 | 0.9999902473 | 0.2991021617 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1507928777 |
| GSE13712_SHEAR | Down | -0.2007193126 |
| GSE13712_STATIC | Down | -0.0389207511 |
| GSE19018 | Down | -0.0559566789 |
| GSE19899_A1 | Down | -0.4141467600 |
| GSE19899_A2 | Down | -0.0453377461 |
| PubMed_21979375_A1 | Down | -0.7173356367 |
| PubMed_21979375_A2 | Down | -0.3050957505 |
| GSE35957 | Down | -0.2001225670 |
| GSE36640 | Up | 0.4262661282 |
| GSE54402 | Down | -0.6797985185 |
| GSE9593 | Up | 0.1530039408 |
| GSE43922 | Down | -0.2871475418 |
| GSE24585 | Up | 0.0733298374 |
| GSE37065 | Up | 0.2070842544 |
| GSE28863_A1 | Down | -0.2629966533 |
| GSE28863_A2 | Up | 0.3806987663 |
| GSE28863_A3 | Down | -0.6548691456 |
| GSE28863_A4 | Down | -0.2817205728 |
| GSE48662 | Down | -0.5453151088 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020479 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021086 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027891 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031391 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048937 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050663 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21562236 | The expression of antioxidant defense genes, such as glutathione peroxidase-1, Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3), were significantly lower in the liver of HF/C pups than in C/C pups |
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