HCSGD entry for TERF2IP
1. General information
| Official gene symbol | TERF2IP |
|---|---|
| Entrez ID | 54386 |
| Gene full name | telomeric repeat binding factor 2, interacting protein |
| Other gene symbols | DRIP5 RAP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | TAS | cellular_component |
| GO:0000723 | Telomere maintenance | IDA TAS | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA ISS | cellular_component |
| GO:0000783 | Nuclear telomere cap complex | IDA | cellular_component |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0007004 | Telomere maintenance via telomerase | TAS | biological_process |
| GO:0010569 | Regulation of double-strand break repair via homologous recombination | ISS | biological_process |
| GO:0010833 | Telomere maintenance via telomere lengthening | ISS | biological_process |
| GO:0030870 | Mre11 complex | IDA | cellular_component |
| GO:0031848 | Protection from non-homologous end joining at telomere | IMP ISS | biological_process |
| GO:0032205 | Negative regulation of telomere maintenance | IDA IMP | biological_process |
| GO:0042162 | Telomeric DNA binding | TAS | molecular_function |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | ISS | biological_process |
| GO:0048239 | Negative regulation of DNA recombination at telomere | ISS | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | ISS | biological_process |
| GO:0070198 | Protein localization to chromosome, telomeric region | IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0147829946 | 0.9858582463 | 0.3028040467 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6225149375 |
| GSE13712_SHEAR | Down | -0.0051866609 |
| GSE13712_STATIC | Down | -0.0467214498 |
| GSE19018 | Up | 0.1086104490 |
| GSE19899_A1 | Up | 0.7286822223 |
| GSE19899_A2 | Up | 0.5929429155 |
| PubMed_21979375_A1 | Up | 0.3409997127 |
| PubMed_21979375_A2 | Up | 0.7749661569 |
| GSE35957 | Down | -0.1149175219 |
| GSE36640 | Up | 0.9361985266 |
| GSE54402 | Up | 0.3932966672 |
| GSE9593 | Up | 0.0752319650 |
| GSE43922 | Up | 0.2147624892 |
| GSE24585 | Up | 0.3051598722 |
| GSE37065 | Up | 0.0316981981 |
| GSE28863_A1 | Up | 0.1185353577 |
| GSE28863_A2 | Up | 0.0918148646 |
| GSE28863_A3 | Down | -0.5419618811 |
| GSE28863_A4 | Up | 0.2004948168 |
| GSE48662 | Up | 0.2418278396 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-590-3p | MIMAT0004801 | MIRT016173 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028687 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031567 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048531 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052183 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
