HCSGD entry for HAO1
1. General information
| Official gene symbol | HAO1 |
|---|---|
| Entrez ID | 54363 |
| Gene full name | hydroxyacid oxidase (glycolate oxidase) 1 |
| Other gene symbols | GOX GOX1 HAOX1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001561 | Fatty acid alpha-oxidation | IDA | biological_process |
| GO:0003973 | (S)-2-hydroxy-acid oxidase activity | IDA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005782 | Peroxisomal matrix | TAS | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008891 | Glycolate oxidase activity | IDA TAS | molecular_function |
| GO:0010181 | FMN binding | IDA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046296 | Glycolate catabolic process | IDA IEA | biological_process |
| GO:0046487 | Glyoxylate metabolic process | TAS | biological_process |
| GO:0047969 | Glyoxylate oxidase activity | TAS | molecular_function |
| GO:0052852 | Very-long-chain-(S)-2-hydroxy-acid oxidase activity | IEA | molecular_function |
| GO:0052853 | Long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity | IEA | molecular_function |
| GO:0052854 | Medium-chain-(S)-2-hydroxy-acid oxidase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8102196307 | 0.7676101402 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0464891659 |
| GSE13712_SHEAR | Up | 0.0089143678 |
| GSE13712_STATIC | Down | -0.0133997526 |
| GSE19018 | Down | -0.0081174756 |
| GSE19899_A1 | Down | -0.0256460996 |
| GSE19899_A2 | Down | -0.1182374960 |
| PubMed_21979375_A1 | Up | 0.0260876819 |
| PubMed_21979375_A2 | Up | 0.0145778914 |
| GSE35957 | Up | 0.2009484827 |
| GSE36640 | Down | -0.0135284755 |
| GSE54402 | Up | 0.0493780740 |
| GSE9593 | Up | 0.0691756399 |
| GSE43922 | Up | 0.0151010817 |
| GSE24585 | Down | -0.0279728519 |
| GSE37065 | Down | -0.0593585998 |
| GSE28863_A1 | Down | -0.1753313459 |
| GSE28863_A2 | Down | -0.1317484238 |
| GSE28863_A3 | Up | 0.0988669610 |
| GSE28863_A4 | Up | 0.1685485093 |
| GSE48662 | Up | 0.0543309424 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-Sulfo-Flavin Mononucleotide | DB02164 | EXPT01464 |
| Benzoylformic Acid | DB02279 | EXPT00053 |
| 3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline | DB03064 | EXPT01195 |
| Riboflavin Monophosphate | DB03247 | EXPT01458 |
| 3-Phenylpyruvic Acid | DB03884 | EXPT02649 |
| 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole | DB04374 | EXPT01787 |
| 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid | DB06979 | - |
| 3-(INDOL-3-YL) LACTATE | DB07060 | - |
| (2S)-2-HYDROXYOCTANOIC ACID | DB07907 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26583057 | Cultured renal cells were treated with glucose oxidase (GOx) for long time periods |
| 26583057 | GOx induced senescence, increasing senescence associated beta-galactosidase activity and the expression of p16 |
| 26583057 | In parallel, GOx increased ILK protein expression and activity |
| 26583057 | Ectopic overexpression of ILK in cells increased p16 expression, even in the absence of GOx, whereas downregulation of ILK inhibited the increase in p16 due to oxidative stress |
| 26583057 | Additionally, GOx reduced Klotho gene expression and cells overexpressing Klotho protein did not undergo senescence after GOx addition |
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