HCSGD entry for WNT4

1. General information

Official gene symbolWNT4
Entrez ID54361
Gene full namewingless-type MMTV integration site family, member 4
Other gene symbolsSERKAL WNT-4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001822Kidney developmentIEPbiological_process
GO:0001837Epithelial to mesenchymal transitionIEPbiological_process
GO:0001838Embryonic epithelial tube formationIEAbiological_process
GO:0001889Liver developmentIEPbiological_process
GO:0003714Transcription corepressor activityIEA ISSmolecular_function
GO:0005102Receptor bindingIEAmolecular_function
GO:0005109Frizzled bindingIBA IEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006702Androgen biosynthetic processIDAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0008584Male gonad developmentIEP IMPbiological_process
GO:0008585Female gonad developmentIEA ISSbiological_process
GO:0009986Cell surfaceIEA ISScellular_component
GO:0010469Regulation of receptor activityICbiological_process
GO:0010629Negative regulation of gene expressionIDAbiological_process
GO:0010894Negative regulation of steroid biosynthetic processIDAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0018345Protein palmitoylationIDAbiological_process
GO:0022407Regulation of cell-cell adhesionIEAbiological_process
GO:0030182Neuron differentiationIBAbiological_process
GO:0030237Female sex determinationIMPbiological_process
GO:0030325Adrenal gland developmentIEPbiological_process
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0030501Positive regulation of bone mineralizationIDAbiological_process
GO:0032321Positive regulation of Rho GTPase activityIEAbiological_process
GO:0032349Positive regulation of aldosterone biosynthetic processIDAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIDAbiological_process
GO:0033080Immature T cell proliferation in thymusIEAbiological_process
GO:0035567Non-canonical Wnt signaling pathwayIEAbiological_process
GO:0038030Non-canonical Wnt signaling pathway via MAPK cascadeIDAbiological_process
GO:0040037Negative regulation of fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0042445Hormone metabolic processIEAbiological_process
GO:0045165Cell fate commitmentIBAbiological_process
GO:0045596Negative regulation of cell differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIDAbiological_process
GO:0045836Positive regulation of meiosisIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEA IMP ISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0048018Receptor agonist activityICmolecular_function
GO:0048599Oocyte developmentIEAbiological_process
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:0051496Positive regulation of stress fiber assemblyIEAbiological_process
GO:0051894Positive regulation of focal adhesion assemblyIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDAbiological_process
GO:0060126Somatotropin secreting cell differentiationIEAbiological_process
GO:0060129Thyroid-stimulating hormone-secreting cell differentiationIEAbiological_process
GO:0060231Mesenchymal to epithelial transitionIEAbiological_process
GO:0060748Tertiary branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0061045Negative regulation of wound healingIEAbiological_process
GO:0061180Mammary gland epithelium developmentIEPbiological_process
GO:0061184Positive regulation of dermatome developmentIDAbiological_process
GO:0061205Paramesonephric duct developmentIMPbiological_process
GO:0061369Negative regulation of testicular blood vessel morphogenesisIMPbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEPbiological_process
GO:0072033Renal vesicle formationIEAbiological_process
GO:0072034Renal vesicle inductionIEAbiological_process
GO:0072162Metanephric mesenchymal cell differentiationNASbiological_process
GO:0072164Mesonephric tubule developmentIEAbiological_process
GO:0072273Metanephric nephron morphogenesisIEAbiological_process
GO:0090002Establishment of protein localization to plasma membraneIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:2000019Negative regulation of male gonad developmentIMPbiological_process
GO:2000066Positive regulation of cortisol biosynthetic processIDAbiological_process
GO:2000225Negative regulation of testosterone biosynthetic processIEA IMPbiological_process
GO:2000273Positive regulation of receptor activityICbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14187445390.94496778240.75638596311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0824649531
GSE13712_SHEARUp0.0439600977
GSE13712_STATICDown-0.1397733623
GSE19018Up0.0767132473
GSE19899_A1Up0.0967207291
GSE19899_A2Up0.1233290463
PubMed_21979375_A1Up0.2346906949
PubMed_21979375_A2Up0.0388897057
GSE35957Up0.0555753515
GSE36640Up0.0582464884
GSE54402Up0.1216089217
GSE9593Down-0.0332428389
GSE43922Up0.0542498091
GSE24585Down-0.1045329606
GSE37065Up0.0749458117
GSE28863_A1Up0.8816560361
GSE28863_A2Up0.6548108743
GSE28863_A3Down-0.0973874773
GSE28863_A4Up0.2495175009
GSE48662Up0.1164018802

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29c-3pMIMAT0000681MIRT006385Luciferase reporter assayFunctional MTI21436257
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.