HCSGD entry for POLG
1. General information
| Official gene symbol | POLG |
|---|---|
| Entrez ID | 5428 |
| Gene full name | polymerase (DNA directed), gamma |
| Other gene symbols | MDP1 MIRAS MTDPS4A MTDPS4B PEO POLG1 POLGA SANDO SCAE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002020 | Protease binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IDA IEA | molecular_function |
| GO:0004527 | Exonuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005760 | Gamma DNA polymerase complex | IEA | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0006264 | Mitochondrial DNA replication | IEA | biological_process |
| GO:0006287 | Base-excision repair, gap-filling | IDA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4962204855 | 0.5293758976 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3005221635 |
| GSE13712_SHEAR | Up | 0.1287211716 |
| GSE13712_STATIC | Down | -0.0171027913 |
| GSE19018 | Up | 0.1739169531 |
| GSE19899_A1 | Up | 0.0660607986 |
| GSE19899_A2 | Up | 0.1266744795 |
| PubMed_21979375_A1 | Down | -0.1038920270 |
| PubMed_21979375_A2 | Up | 0.0694604953 |
| GSE35957 | Down | -0.2353400216 |
| GSE36640 | Down | -0.0704987115 |
| GSE54402 | Up | 0.2763844358 |
| GSE9593 | Down | -0.2035476391 |
| GSE43922 | Up | 0.4905576801 |
| GSE24585 | Down | -0.2903016450 |
| GSE37065 | Down | -0.0649283082 |
| GSE28863_A1 | Up | 0.3165678336 |
| GSE28863_A2 | Up | 0.2631893538 |
| GSE28863_A3 | Down | -0.2179124642 |
| GSE28863_A4 | Up | 0.0086914326 |
| GSE48662 | Down | -0.3099262712 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028963 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038412 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039938 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041750 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046950 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19403001 | On the other hand, recent studies on mitochondrial mutant mice, which carry a proofreading deficient subunit of DNA polymerase gamma, revealed that mtDNA mutations accumulated in somatic tissues in the mice that displayed prominent features of aging |
| 19244310 | Expression of a proof-reading deficient form of mitochondrial DNA (mtDNA) polymerase gamma, POLG, causes early death accompanied by features of premature ageing in mouse |
| 19244310 | In addition to high levels of point mutations of mtDNA, the POLG mutator mouse harbours linear mtDNAs |
| 19244310 | Pausing at these sites may be enhanced in the case of exonuclease-deficient POLG owing to delayed resumption of DNA replication, or replisome instability |
| 19244310 | In either case, the mtDNA replication cycle is perturbed and this might explain the progeroid features of the POLG mutator mouse |
| 16132531 | AZT is also known to inhibit reverse transcriptase, as well as other cellular enzymes including DNA polymerase gamma, thymidine kinase, and telomerase |
| 7300456 | DNA polymerase-gamma accounts for 5% of the polymerase activity in young cells and 20% in old cells |
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