HCSGD entry for POLE2
1. General information
| Official gene symbol | POLE2 |
|---|---|
| Entrez ID | 5427 |
| Gene full name | polymerase (DNA directed), epsilon 2, accessory subunit |
| Other gene symbols | DPE2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000722 | Telomere maintenance via recombination | TAS | biological_process |
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006297 | Nucleotide-excision repair, DNA gap filling | TAS | biological_process |
| GO:0008622 | Epsilon DNA polymerase complex | IDA | cellular_component |
| GO:0032201 | Telomere maintenance via semi-conservative replication | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9926091372 | 0.0000282892 | 0.9999902473 | 0.0094253165 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6294709811 |
| GSE13712_SHEAR | Down | -0.2205342328 |
| GSE13712_STATIC | Down | -0.1975918622 |
| GSE19018 | Down | -0.3930855323 |
| GSE19899_A1 | Down | -0.6889223504 |
| GSE19899_A2 | Down | -4.7165646991 |
| PubMed_21979375_A1 | Down | -1.4417292039 |
| PubMed_21979375_A2 | Down | -6.4845244517 |
| GSE35957 | Down | -2.6257076382 |
| GSE36640 | Down | -4.6042378513 |
| GSE54402 | Down | -0.4477906660 |
| GSE9593 | Down | -1.9707491388 |
| GSE43922 | Down | -2.1778619117 |
| GSE24585 | Down | -0.1362521719 |
| GSE37065 | Down | -0.4539122637 |
| GSE28863_A1 | Down | -0.1755221256 |
| GSE28863_A2 | Up | 0.1830720948 |
| GSE28863_A3 | Down | -0.4575129610 |
| GSE28863_A4 | Up | 0.2148813717 |
| GSE48662 | Down | -1.2073313689 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016554 | Microarray | Functional MTI (Weak) | 20304954 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
