HCSGD entry for POLB

1. General information

Official gene symbolPOLB
Entrez ID5423
Gene full namepolymerase (DNA directed), beta
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEAmolecular_function
GO:0003684Damaged DNA bindingIEAmolecular_function
GO:0003887DNA-directed DNA polymerase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005876Spindle microtubuleIDAcellular_component
GO:0006261DNA-dependent DNA replicationTASbiological_process
GO:0006281DNA repairIEA TASbiological_process
GO:0006284Base-excision repairIDA IMP TASbiological_process
GO:0006287Base-excision repair, gap-fillingIEAbiological_process
GO:0006290Pyrimidine dimer repairIEAbiological_process
GO:0006297Nucleotide-excision repair, DNA gap fillingIMPbiological_process
GO:0006974Cellular response to DNA damage stimulusIMPbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
GO:0016779Nucleotidyltransferase activityIEAmolecular_function
GO:0016829Lyase activityIDAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0045471Response to ethanolIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051402Neuron apoptotic processIEAbiological_process
GO:0071897DNA biosynthetic processIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89750419440.21544708410.99999024730.8951825154

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0239696498
GSE13712_SHEARDown-0.2102538192
GSE13712_STATICDown-0.1111972803
GSE19018Up0.0956718901
GSE19899_A1Down-0.0738023248
GSE19899_A2Down-0.3191483959
PubMed_21979375_A1Up0.5932912468
PubMed_21979375_A2Down-0.0574959363
GSE35957Down-0.1765773338
GSE36640Down-0.5119417980
GSE54402Up0.1409848822
GSE9593Down-0.1149170114
GSE43922Down-0.2094129997
GSE24585Up0.1299073505
GSE37065Up0.0328018846
GSE28863_A1Down-0.0958979950
GSE28863_A2Up0.1819389033
GSE28863_A3Down-0.1135069841
GSE28863_A4Down-0.0459028398
GSE48662Down-0.2466181439

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2'-Deoxyadenosine 5'-TriphosphateDB03222 EXPT01288
(1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOLDB07479 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1301-3pMIMAT0005797MIRT035975CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051150CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.