HCSGD entry for CYCS
1. General information
| Official gene symbol | CYCS |
|---|---|
| Entrez ID | 54205 |
| Gene full name | cytochrome c, somatic |
| Other gene symbols | CYC HCS THC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000159 | Protein phosphatase type 2A complex | TAS | cellular_component |
| GO:0004722 | Protein serine/threonine phosphatase activity | TAS | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | TAS | cellular_component |
| GO:0005829 | Cytosol | IMP TAS | cellular_component |
| GO:0006309 | Apoptotic DNA fragmentation | IMP | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0008635 | Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c | TAS | biological_process |
| GO:0009055 | Electron carrier activity | IEA | molecular_function |
| GO:0016311 | Dephosphorylation | TAS | biological_process |
| GO:0020037 | Heme binding | IEA TAS | molecular_function |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045155 | Electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity | IDA | molecular_function |
| GO:0045333 | Cellular respiration | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IEA | biological_process |
| GO:0070469 | Respiratory chain | IEA | cellular_component |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2406934615 | 0.0260681699 | 0.9275684627 | 0.3093509017 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0942606716 |
| GSE13712_SHEAR | Up | 0.1086244122 |
| GSE13712_STATIC | Up | 0.0249451751 |
| GSE19018 | Down | -0.5361210819 |
| GSE19899_A1 | Down | -0.0715992495 |
| GSE19899_A2 | Up | 0.5747807123 |
| PubMed_21979375_A1 | Up | 0.0390784586 |
| PubMed_21979375_A2 | Up | 0.9932498866 |
| GSE35957 | Up | 0.5193944764 |
| GSE36640 | Up | 0.3599480080 |
| GSE54402 | Up | 0.3135546467 |
| GSE9593 | Down | -0.0693731044 |
| GSE43922 | Up | 0.0574230586 |
| GSE24585 | Down | -0.3333434695 |
| GSE37065 | Down | -0.1531048042 |
| GSE28863_A1 | Down | -0.5259453310 |
| GSE28863_A2 | Down | -1.7377449778 |
| GSE28863_A3 | Down | -0.7783191514 |
| GSE28863_A4 | Down | -0.0352223518 |
| GSE48662 | Down | -0.4404620795 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Minocycline | DB01017 | APRD00547 |
| Protoporphyrin Ix Containing Co | DB02110 | EXPT00984 |
| Heme C | DB03317 | EXPT01722 |
| Protoporphyrin Ix Containing Zn | DB03934 | EXPT03292 |
| N-Trimethyllysine | DB03977 | EXPT02087 |
| Zinc Substituted Heme C | DB04249 | EXPT01728 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148a-3p | MIMAT0000243 | MIRT025976 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031466 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-320c | MIMAT0005793 | MIRT036158 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038787 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044075 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22140513 | Our results show that the inhibitory effect of dp53 on ectopic neuroblast formation was mediated largely through its regulation of Cyclin E (Cyc E) |
| 22140513 | Overexpression of Cyc E was able to abrogate dp53's ability to rescue numb loss-of-function phenotypes |
| 22140513 | Increasing Cyc E levels by attenuating Archipelago (Ago), a recently identified transcriptional target of dp53 and a negative regulator of Cyc E, had similar effects |
| 22140513 | Conversely, reducing Cyc E activity by overexpressing Ago blocked ectopic neuroblast formation in numb mutant |
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