HCSGD entry for PNMT

1. General information

Official gene symbolPNMT
Entrez ID5409
Gene full namephenylethanolamine N-methyltransferase
Other gene symbolsPENT PNMTase
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004603Phenylethanolamine N-methyltransferase activityIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0008168Methyltransferase activityIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042418Epinephrine biosynthetic processIEAbiological_process
GO:0042423Catecholamine biosynthetic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67821120780.51848332890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1597135207
GSE13712_SHEARUp0.1614002115
GSE13712_STATICDown-0.1892575904
GSE19018Up0.0698582596
GSE19899_A1Up0.1009250185
GSE19899_A2Down-0.0788131727
PubMed_21979375_A1Up0.1832552089
PubMed_21979375_A2Down-0.4142006392
GSE35957Up0.0672749417
GSE36640Up0.2246785030
GSE54402Up0.0778149548
GSE9593Up0.1581014379
GSE43922Up0.0452308923
GSE24585Down-0.1833233713
GSE37065Down-0.1792886423
GSE28863_A1Up0.1464225569
GSE28863_A2Down-0.0957729330
GSE28863_A3Up0.2426132413
GSE28863_A4Down-0.0413712359
GSE48662Up0.0021000102

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

S-Adenosyl-L-HomocysteineDB01752 EXPT02842
1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid AmideDB03468 EXPT02913
7-Iodo-1,2,3,4-Tetrahydro-IsoquinolineDB03824 EXPT01840
8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]AzepineDB04273 EXPT02072
CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OLDB07597 -
(3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINEDB07739 -
(3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDEDB07747 -
(3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDEDB07798 -
[(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOLDB07906 -
(1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amineDB08128 -
(1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanolDB08129 -
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINEDB08550 -
N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDEDB08631 -
TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OLDB08654 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029157MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.