HCSGD entry for EXOSC10
1. General information
| Official gene symbol | EXOSC10 |
|---|---|
| Entrez ID | 5394 |
| Gene full name | exosome component 10 |
| Other gene symbols | PM-Scl PM/Scl-100 PMSCL PMSCL2 RRP6 Rrp6p p2 p3 p4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000176 | Nuclear exosome (RNase complex) | IEA | cellular_component |
| GO:0000178 | Exosome (RNase complex) | IDA | cellular_component |
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IMP | biological_process |
| GO:0000460 | Maturation of 5.8S rRNA | IMP | biological_process |
| GO:0000956 | Nuclear-transcribed mRNA catabolic process | IMP | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004532 | Exoribonuclease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006396 | RNA processing | IEA | biological_process |
| GO:0008408 | 3'-5' exonuclease activity | IEA | molecular_function |
| GO:0009048 | Dosage compensation by inactivation of X chromosome | IEA | biological_process |
| GO:0035327 | Transcriptionally active chromatin | IMP | cellular_component |
| GO:0071028 | Nuclear mRNA surveillance | IMP | biological_process |
| GO:0071034 | CUT catabolic process | IMP | biological_process |
| GO:0071035 | Nuclear polyadenylation-dependent rRNA catabolic process | IMP | biological_process |
| GO:0071044 | Histone mRNA catabolic process | IMP | biological_process |
| GO:0071048 | Nuclear retention of unspliced pre-mRNA at the site of transcription | IMP | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | IDA | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7788249041 | 0.4625680065 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0652907899 |
| GSE13712_SHEAR | Up | 0.0522736786 |
| GSE13712_STATIC | Down | -0.0440095227 |
| GSE19018 | Down | -0.0022436498 |
| GSE19899_A1 | Up | 0.1044682299 |
| GSE19899_A2 | Down | -0.0378859762 |
| PubMed_21979375_A1 | Down | -0.1120176909 |
| PubMed_21979375_A2 | Up | 0.2202646192 |
| GSE35957 | Down | -0.3075628426 |
| GSE36640 | Down | -0.5343638945 |
| GSE54402 | Up | 0.1324154272 |
| GSE9593 | Down | -0.1671332718 |
| GSE43922 | Down | -0.0212460450 |
| GSE24585 | Up | 0.2053206215 |
| GSE37065 | Up | 0.0906540805 |
| GSE28863_A1 | Up | 0.1627130425 |
| GSE28863_A2 | Up | 0.4495381047 |
| GSE28863_A3 | Down | -0.2913748929 |
| GSE28863_A4 | Down | -0.1944293959 |
| GSE48662 | Down | -0.2126071383 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028551 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041296 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041716 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046671 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
