HCSGD entry for PMP22
1. General information
| Official gene symbol | PMP22 |
|---|---|
| Entrez ID | 5376 |
| Gene full name | peripheral myelin protein 22 |
| Other gene symbols | CMT1A CMT1E DSS GAS-3 HMSNIA HNPP Sp110 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005923 | Tight junction | IEA | cellular_component |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007422 | Peripheral nervous system development | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0010977 | Negative regulation of neuron projection development | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0032288 | Myelin assembly | IEA | biological_process |
| GO:0043218 | Compact myelin | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3088330155 | 0.1148741499 | 0.9999902473 | 0.6492405539 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0183191933 |
| GSE13712_SHEAR | Up | 1.2107127315 |
| GSE13712_STATIC | Up | 0.2088426880 |
| GSE19018 | Down | -0.8415376875 |
| GSE19899_A1 | Down | -0.5960927889 |
| GSE19899_A2 | Down | -0.3023659068 |
| PubMed_21979375_A1 | Down | -0.2334424523 |
| PubMed_21979375_A2 | Down | -0.2682182329 |
| GSE35957 | Up | 0.2160313503 |
| GSE36640 | Up | 0.1108582752 |
| GSE54402 | Down | -0.3241487825 |
| GSE9593 | Up | 0.2695746715 |
| GSE43922 | Down | -0.9974707578 |
| GSE24585 | Up | 0.3238826331 |
| GSE37065 | Up | 0.2029481733 |
| GSE28863_A1 | Up | 0.2150327736 |
| GSE28863_A2 | Up | 0.2444091071 |
| GSE28863_A3 | Down | -0.1057190283 |
| GSE28863_A4 | Up | 0.0043805757 |
| GSE48662 | Down | -0.0595010457 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023386 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029747 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10579901 | The gas3/PMP22 gene product is a dual function protein, involved in both peripheral nerve myelination and cell proliferation |
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