HCSGD entry for PLSCR1

1. General information

Official gene symbolPLSCR1
Entrez ID5359
Gene full namephospholipid scramblase 1
Other gene symbolsMMTRA1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005154Epidermal growth factor receptor bindingIPImolecular_function
GO:0005509Calcium ion bindingIDA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006659Phosphatidylserine biosynthetic processISSbiological_process
GO:0006810TransportIDAbiological_process
GO:0006869Lipid transportIDAbiological_process
GO:0006915Apoptotic processIDAbiological_process
GO:0006953Acute-phase responseISSbiological_process
GO:0010628Positive regulation of gene expressionIMPbiological_process
GO:0015914Phospholipid transportIDAbiological_process
GO:0017121Phospholipid scramblingIDAbiological_process
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0017128Phospholipid scramblase activityIDAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0030168Platelet activationNASbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0033003Regulation of mast cell activationISSbiological_process
GO:0035456Response to interferon-betaIMPbiological_process
GO:0042609CD4 receptor bindingIPImolecular_function
GO:0045071Negative regulation of viral genome replicationIMPbiological_process
GO:0045089Positive regulation of innate immune responseIMPbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0051607Defense response to virusIMPbiological_process
GO:0060368Regulation of Fc receptor mediated stimulatory signaling pathwayISSbiological_process
GO:2000373Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03720023560.03623513540.43640155140.3584160090

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5507586274
GSE13712_SHEARUp0.9268439463
GSE13712_STATICUp0.5703617497
GSE19018Down-0.2231863812
GSE19899_A1Down-0.4208911826
GSE19899_A2Down-1.1939774264
PubMed_21979375_A1Down-0.7010094790
PubMed_21979375_A2Down-0.9755349844
GSE35957Down-1.5073865282
GSE36640Down-0.0873516158
GSE54402Down-0.0290107736
GSE9593Down-0.1117847237
GSE43922Down-0.5347637884
GSE24585Up1.2518891398
GSE37065Up0.9849117629
GSE28863_A1Up0.7618455098
GSE28863_A2Up1.6940191044
GSE28863_A3Down-0.4103418753
GSE28863_A4Down-0.1397763383
GSE48662Down-0.3377234315

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021730MicroarrayFunctional MTI (Weak)17612493
hsa-miR-18a-3pMIMAT0002891MIRT040909CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047725CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048655CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.