HCSGD entry for PLOD2
1. General information
| Official gene symbol | PLOD2 |
|---|---|
| Entrez ID | 5352 |
| Gene full name | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| Other gene symbols | LH2 TLH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEP | biological_process |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005581 | Collagen | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0008475 | Procollagen-lysine 5-dioxygenase activity | IEA | molecular_function |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030867 | Rough endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0011618556 | 0.8461688804 | 0.0914668657 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3524314490 |
| GSE13712_SHEAR | Up | 0.9221993355 |
| GSE13712_STATIC | Up | 0.7952138892 |
| GSE19018 | Up | 1.6751743742 |
| GSE19899_A1 | Up | 0.9209097923 |
| GSE19899_A2 | Up | 0.7165354719 |
| PubMed_21979375_A1 | Up | 1.7954812804 |
| PubMed_21979375_A2 | Up | 0.7573261122 |
| GSE35957 | Down | -0.6663075924 |
| GSE36640 | Up | 0.4211404558 |
| GSE54402 | Up | 0.1756381509 |
| GSE9593 | Up | 0.1141609871 |
| GSE43922 | Up | 1.0504654535 |
| GSE24585 | Up | 0.2253484293 |
| GSE37065 | Up | 0.0501083877 |
| GSE28863_A1 | Up | 0.2923156520 |
| GSE28863_A2 | Up | 0.8117493432 |
| GSE28863_A3 | Down | -0.0505478366 |
| GSE28863_A4 | Down | -0.5483176482 |
| GSE48662 | Up | 0.1184882037 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT024186 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027724 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029832 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039306 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040384 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052752 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
