HCSGD entry for PLN


1. General information

Official gene symbolPLN
Entrez ID5350
Gene full namephospholamban
Other gene symbolsCMD1P CMH18 PLB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002026Regulation of the force of heart contractionICbiological_process
GO:0004857Enzyme inhibitor activityISSmolecular_function
GO:0005246Calcium channel regulator activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumISScellular_component
GO:0006816Calcium ion transportIEAbiological_process
GO:0008015Blood circulationNASbiological_process
GO:0008016Regulation of heart contractionIMPbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0010459Negative regulation of heart rateIMPbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIEAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0031982VesicleIEAcellular_component
GO:0032780Negative regulation of ATPase activityIDA ISSbiological_process
GO:0033017Sarcoplasmic reticulum membraneIEAcellular_component
GO:0033574Response to testosteroneIEAbiological_process
GO:0042030ATPase inhibitor activityIDA ISSmolecular_function
GO:0042802Identical protein bindingISSmolecular_function
GO:0043086Negative regulation of catalytic activityISSbiological_process
GO:0048471Perinuclear region of cytoplasmISScellular_component
GO:0048738Cardiac muscle tissue developmentIEAbiological_process
GO:0051117ATPase bindingISSmolecular_function
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051480Cytosolic calcium ion homeostasisICbiological_process
GO:0051924Regulation of calcium ion transportIDA ISSbiological_process
GO:0051926Negative regulation of calcium ion transportIDAbiological_process
GO:0055119Relaxation of cardiac muscleTASbiological_process
GO:0060314Regulation of ryanodine-sensitive calcium-release channel activityIEAbiological_process
GO:0086004Regulation of cardiac muscle cell contractionICbiological_process
GO:0086023Adrenergic receptor signaling pathway involved in heart processIEAbiological_process
GO:0086036Regulation of cardiac muscle cell membrane potentialICbiological_process
GO:0086092Regulation of the force of heart contraction by cardiac conductionIEAbiological_process
GO:0090281Negative regulation of calcium ion importISSbiological_process
GO:0090534Calcium ion-transporting ATPase complexIDAcellular_component
GO:1901020Negative regulation of calcium ion transmembrane transporter activityIDA ISSbiological_process
GO:1901877Negative regulation of calcium ion bindingIDA ISSbiological_process
GO:1901894Regulation of calcium-transporting ATPase activityIDAbiological_process
GO:1901895Negative regulation of calcium-transporting ATPase activityIDAbiological_process
GO:1901897Regulation of relaxation of cardiac muscleICbiological_process
GO:1902081Negative regulation of calcium ion import into sarcoplasmic reticulumISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96721811100.01560389800.99999024730.2446159619

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.1221184357
GSE13712_SHEARDown-0.2173712821
GSE13712_STATICDown-0.1032990485
GSE19018Down-0.2345749333
GSE19899_A1Up0.0726679931
GSE19899_A2Down-0.1370988320
PubMed_21979375_A1Down-0.1439965053
PubMed_21979375_A2Down-0.0726568950
GSE35957Up0.1232178376
GSE36640Down-0.1086732357
GSE54402Down-0.0357923210
GSE9593Up0.1318875139
GSE43922Up0.0138417745
GSE24585Up0.3759620531
GSE37065Down-0.0496152119
GSE28863_A1Down-0.0119912131
GSE28863_A2Down-2.0152378249
GSE28863_A3Down-0.4325366552
GSE28863_A4Down-0.5998377764
GSE48662Down-0.0228700567

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.