HCSGD entry for SERPINF2

1. General information

Official gene symbolSERPINF2
Entrez ID5345
Gene full nameserpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Other gene symbolsA2AP AAP ALPHA-2-PI API PLI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002020Protease bindingIPImolecular_function
GO:0002034Regulation of blood vessel size by renin-angiotensinIEA ISSbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0004866Endopeptidase inhibitor activityTASmolecular_function
GO:0004867Serine-type endopeptidase inhibitor activityIBA IDA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005577Fibrinogen complexIDAcellular_component
GO:0005615Extracellular spaceIBA IDA IEAcellular_component
GO:0006953Acute-phase responseIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010033Response to organic substanceIEAbiological_process
GO:0010757Negative regulation of plasminogen activationIDAbiological_process
GO:0010951Negative regulation of endopeptidase activityIBAbiological_process
GO:0030162Regulation of proteolysisIBAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030199Collagen fibril organizationIEA ISSbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0032967Positive regulation of collagen biosynthetic processIDA IEAbiological_process
GO:0042730FibrinolysisTASbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0045597Positive regulation of cell differentiationIDA IEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0048514Blood vessel morphogenesisIEA ISSbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEA ISSbiological_process
GO:0051496Positive regulation of stress fiber assemblyIDAbiological_process
GO:0051918Negative regulation of fibrinolysisIDA IEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0071636Positive regulation of transforming growth factor beta productionIDA IEAbiological_process
GO:2000049Positive regulation of cell-cell adhesion mediated by cadherinTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57576569280.74269509900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1550636699
GSE13712_SHEARDown-0.0783990845
GSE13712_STATICDown-0.0375556609
GSE19018Down-0.0737905067
GSE19899_A1Up0.0250824705
GSE19899_A2Up0.0712830717
PubMed_21979375_A1Up0.0859485420
PubMed_21979375_A2Down-0.0139570536
GSE35957Up0.0346230581
GSE36640Down-0.0051044419
GSE54402Down-0.0484662510
GSE9593Up0.0568027005
GSE43922Up0.0343027500
GSE24585Up0.0620582042
GSE37065Down-0.1041907159
GSE28863_A1Down-0.1598039492
GSE28863_A2Down-0.2381826397
GSE28863_A3Up0.4354882740
GSE28863_A4Up0.2330695370
GSE48662Up0.0976765375

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OcriplasminDB08888 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25377220PURPOSE: To investigate effects of aging on endothelial nitric oxide synthase (eNOS) expression and signaling in angular aqueous plexus (AAP) (functional equivalent to human Schlemm's canal) cells subjected to shear stress
23735887RESULTS: H2O2 and API, separately, increased oxidative stress and mitochondrial dysfunction, apoptosis and cell senescence
23735887When H2O2 and API were delivered concurrently, their detrimental effects on renal cell loss were compounded
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