HCSGD entry for PLD2
1. General information
| Official gene symbol | PLD2 |
|---|---|
| Entrez ID | 5338 |
| Gene full name | phospholipase D2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002031 | G-protein coupled receptor internalization | IEA | biological_process |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004630 | Phospholipase D activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006654 | Phosphatidic acid biosynthetic process | TAS | biological_process |
| GO:0006655 | Phosphatidylglycerol biosynthetic process | TAS | biological_process |
| GO:0007010 | Cytoskeleton organization | TAS | biological_process |
| GO:0007154 | Cell communication | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0031526 | Brush border membrane | IEA | cellular_component |
| GO:0035091 | Phosphatidylinositol binding | IEA | molecular_function |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0070290 | NAPE-specific phospholipase D activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5469782759 | 0.1492305536 | 0.9999902473 | 0.7468905495 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1494639147 |
| GSE13712_SHEAR | Down | -0.6627335382 |
| GSE13712_STATIC | Down | -0.1972901425 |
| GSE19018 | Up | 0.3141486476 |
| GSE19899_A1 | Down | -0.1144641758 |
| GSE19899_A2 | Up | 0.1869448165 |
| PubMed_21979375_A1 | Up | 0.0422672775 |
| PubMed_21979375_A2 | Up | 0.2715342183 |
| GSE35957 | Down | -0.2023630112 |
| GSE36640 | Down | -0.1325373517 |
| GSE54402 | Down | -0.0667100697 |
| GSE9593 | Down | -0.2531133079 |
| GSE43922 | Up | 0.0280439586 |
| GSE24585 | Up | 0.3075154007 |
| GSE37065 | Down | -0.1609669631 |
| GSE28863_A1 | Up | 0.3987476045 |
| GSE28863_A2 | Down | -0.4816099050 |
| GSE28863_A3 | Down | -0.0546040292 |
| GSE28863_A4 | Down | -0.0546618303 |
| GSE48662 | Down | -0.0251505153 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Choline | DB00122 | NUTR00020 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26703243 | Regulation of protein kinase CK2 catalytic activity by protein kinase C and phospholipase D2 |
| 26703243 | We have previously demonstrated that phospholipase D2 (PLD2) overexpression antagonizes protein kinase CK2 (CK2) inhibition-mediated cellular senescence |
| 26703243 | In the current paper, we show the molecular mechanism of CK2 activation by PLD2 and protein kinase C (PKC) |
| 26703243 | Elevated expression and chemical activation of PLD2 increased the catalytic activity of CK2 and PKC in human colon cancer HCT116 and embryonic kidney HEK293 cells, whereas utilization of PLD2 chemical inhibitors and siRNA suppressed this activity |
| 26703243 | Inhibition of PKC in these cells suppressed PLD2-induced CK2 activation, suggesting that PLD2 enhances CK2 activity through PKC |
| 26703243 | Taken together, the present results suggest that PLD2 can stimulate CK2 activity through PKC-mediated CK2alpha phosphorylation |
| 25064843 | Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1/WAF1 pathway |
| 25064843 | The expression of phospholipase D1 (PLD1) and PLD2 were found to decrease at the transcription level during both replicative and premature senescence in human lung fibroblast IMR-90 cells |
| 25064843 | Knockdown of PLD2 dramatically induced senescent phenotype in proliferating IMR-90 cells and wild-type HCT116 colon cancer cells, whereas this response was nearly abolished in p53- or p21(Cip1/WAF1)-null HCT116 cells |
| 25064843 | PLD2 knockdown increased the intracellular reactive oxygen species (ROS) |
| 25064843 | PLD2 overexpression increased protein kinase CK2 (also known as casein kinase 2) (CK2) activity |
| 25064843 | Taken together, these results show that PLD2 downregulation causes senescence through the p53-p21(Cip1/WAF1) pathway by stimulating ROS production, which is induced by CK2 inhibition |
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