HCSGD entry for PLD1
1. General information
| Official gene symbol | PLD1 |
|---|---|
| Entrez ID | 5337 |
| Gene full name | phospholipase D1, phosphatidylcholine-specific |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004630 | Phospholipase D activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006654 | Phosphatidic acid biosynthetic process | TAS | biological_process |
| GO:0006655 | Phosphatidylglycerol biosynthetic process | TAS | biological_process |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0007154 | Cell communication | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0031902 | Late endosome membrane | IEA | cellular_component |
| GO:0035091 | Phosphatidylinositol binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050830 | Defense response to Gram-positive bacterium | IEA | biological_process |
| GO:0070290 | NAPE-specific phospholipase D activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0037883173 | 0.9819776984 | 0.1648137190 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2431812112 |
| GSE13712_SHEAR | Down | -0.1657156224 |
| GSE13712_STATIC | Up | 0.3928852350 |
| GSE19018 | Up | 0.2466891047 |
| GSE19899_A1 | Up | 0.1912544820 |
| GSE19899_A2 | Up | 1.1943248923 |
| PubMed_21979375_A1 | Up | 0.2571111859 |
| PubMed_21979375_A2 | Up | 0.6197651738 |
| GSE35957 | Down | -0.2275682896 |
| GSE36640 | Up | 0.5049796715 |
| GSE54402 | Down | -0.0804259515 |
| GSE9593 | Down | -0.0407157908 |
| GSE43922 | Up | 1.1840017800 |
| GSE24585 | Up | 0.3000506286 |
| GSE37065 | Up | 0.6310632182 |
| GSE28863_A1 | Up | 1.2239426426 |
| GSE28863_A2 | Up | 1.3872940632 |
| GSE28863_A3 | Up | 0.1414869635 |
| GSE28863_A4 | Down | -0.0729847169 |
| GSE48662 | Down | -0.1549192467 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT031003 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25064843 | The expression of phospholipase D1 (PLD1) and PLD2 were found to decrease at the transcription level during both replicative and premature senescence in human lung fibroblast IMR-90 cells |
| 22178194 | Affymetrix gene array data showed NeuT-induced alterations in the transcription of many enzymes involved in lipid metabolism, several of which (ACSL3, CHPT1, PLD1, LIPG, MGLL, LDL and NPC1) could be confirmed by quantitative realtime PCR |
| 12086695 | The protein levels of PKC-alpha and PLC-gamma1 were unchanged, but those of PLD1 and PDGFR were reduced with age |
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