HCSGD entry for PLCG2

1. General information

Official gene symbolPLCG2
Entrez ID5336
Gene full namephospholipase C, gamma 2 (phosphatidylinositol-specific)
Other gene symbolsAPLAID FCAS3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002316Follicular B cell differentiationIEAbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityIDA IEA TASmolecular_function
GO:0004629Phospholipase C activityTASmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006629Lipid metabolic processIEAbiological_process
GO:0006661Phosphatidylinositol biosynthetic processIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008081Phosphoric diester hydrolase activityIEAmolecular_function
GO:0009395Phospholipid catabolic processIEAbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0016055Wnt signaling pathwayTASbiological_process
GO:0019722Calcium-mediated signalingNASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030183B cell differentiationISSbiological_process
GO:0032237Activation of store-operated calcium channel activityIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032959Inositol trisphosphate biosynthetic processIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043069Negative regulation of programmed cell deathIEAbiological_process
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0050852T cell receptor signaling pathwayIEA ISSbiological_process
GO:0050853B cell receptor signaling pathwayIEA ISSbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81707468940.70496970100.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0182607966
GSE13712_SHEARDown-0.5867857524
GSE13712_STATICUp0.1716367056
GSE19018Up0.1085629143
GSE19899_A1Up0.1014124344
GSE19899_A2Up0.0892516465
PubMed_21979375_A1Up0.2995556922
PubMed_21979375_A2Up0.0565409846
GSE35957Up0.0689495031
GSE36640Down-0.0037454712
GSE54402Up0.1316767312
GSE9593Up0.0348538375
GSE43922Up0.0099448146
GSE24585Down-0.0703198189
GSE37065Down-0.0394546161
GSE28863_A1Down-0.2312936661
GSE28863_A2Down-0.1544557638
GSE28863_A3Up0.2215773685
GSE28863_A4Up0.0284102412
GSE48662Down-0.0794990402

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019144MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.