HCSGD entry for SHC3
1. General information
| Official gene symbol | SHC3 |
|---|---|
| Entrez ID | 53358 |
| Gene full name | SHC (Src homology 2 domain containing) transforming protein 3 |
| Other gene symbols | N-Shc NSHC RAI SHCC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007417 | Central nervous system development | TAS | biological_process |
| GO:0007611 | Learning or memory | IEA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0035249 | Synaptic transmission, glutamatergic | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0124687626 | 0.9471564948 | 0.2791085739 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2279338262 |
| GSE13712_SHEAR | Down | -0.3563985119 |
| GSE13712_STATIC | Down | -0.2818957139 |
| GSE19018 | Up | 0.1930591831 |
| GSE19899_A1 | Up | 0.2410777207 |
| GSE19899_A2 | Up | 0.3024341647 |
| PubMed_21979375_A1 | Up | 0.6160771939 |
| PubMed_21979375_A2 | Up | 0.8332717054 |
| GSE35957 | Up | 1.8137647805 |
| GSE36640 | Down | -0.0932870714 |
| GSE54402 | Up | 0.4881218576 |
| GSE9593 | Up | 0.1136870258 |
| GSE43922 | Up | 0.2693044487 |
| GSE24585 | Down | -0.0558297785 |
| GSE37065 | Up | 0.1469419750 |
| GSE28863_A1 | Up | 0.4905919187 |
| GSE28863_A2 | Up | 1.2565327694 |
| GSE28863_A3 | Down | -0.0207486973 |
| GSE28863_A4 | Up | 0.2387573086 |
| GSE48662 | Down | -0.1214595592 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002724 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018309 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049052 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
