HCSGD entry for PLCG1
1. General information
| Official gene symbol | PLCG1 |
|---|---|
| Entrez ID | 5335 |
| Gene full name | phospholipase C, gamma 1 |
| Other gene symbols | NCKAP3 PLC-II PLC1 PLC148 PLCgamma1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | TAS | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001726 | Ruffle | IDA | cellular_component |
| GO:0004435 | Phosphatidylinositol phospholipase C activity | IDA TAS | molecular_function |
| GO:0004629 | Phospholipase C activity | TAS | molecular_function |
| GO:0005057 | Receptor signaling protein activity | NAS | molecular_function |
| GO:0005168 | Neurotrophin TRKA receptor binding | IPI | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0007165 | Signal transduction | NAS TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008180 | COP9 signalosome | IDA | cellular_component |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009395 | Phospholipid catabolic process | IEA | biological_process |
| GO:0010634 | Positive regulation of epithelial cell migration | IMP | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030971 | Receptor tyrosine kinase binding | IEA | molecular_function |
| GO:0035254 | Glutamate receptor binding | IEA | molecular_function |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0043536 | Positive regulation of blood vessel endothelial cell migration | IDA | biological_process |
| GO:0043647 | Inositol phosphate metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IDA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0071364 | Cellular response to epidermal growth factor stimulus | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6418675316 | 0.7426379431 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1034288158 |
| GSE13712_SHEAR | Up | 0.0948155615 |
| GSE13712_STATIC | Up | 0.0087012150 |
| GSE19018 | Down | -0.1559430360 |
| GSE19899_A1 | Up | 0.0199968981 |
| GSE19899_A2 | Down | -0.0979853371 |
| PubMed_21979375_A1 | Down | -0.0044857153 |
| PubMed_21979375_A2 | Up | 0.0402510938 |
| GSE35957 | Down | -0.0571156471 |
| GSE36640 | Down | -0.1062501137 |
| GSE54402 | Up | 0.1289592615 |
| GSE9593 | Up | 0.1251054341 |
| GSE43922 | Down | -0.0113022546 |
| GSE24585 | Up | 0.0535009253 |
| GSE37065 | Down | -0.1826660416 |
| GSE28863_A1 | Up | 0.3110075415 |
| GSE28863_A2 | Up | 0.4382665053 |
| GSE28863_A3 | Down | -0.0087430715 |
| GSE28863_A4 | Up | 0.0055269696 |
| GSE48662 | Down | -0.1452647362 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025369 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-1914-3p | MIMAT0007890 | MIRT035779 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-3p | MIMAT0004946 | MIRT037381 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049488 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12086695 | The protein levels of PKC-alpha and PLC-gamma1 were unchanged, but those of PLD1 and PDGFR were reduced with age |
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