HCSGD entry for PLCB3


1. General information

Official gene symbolPLCB3
Entrez ID5331
Gene full namephospholipase C, beta 3 (phosphatidylinositol-specific)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003073Regulation of systemic arterial blood pressureIDAbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityIEAmolecular_function
GO:0004629Phospholipase C activityTASmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005516Calmodulin bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0007268Synaptic transmissionTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016042Lipid catabolic processIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48584654840.57467192740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0553966975
GSE13712_SHEARDown-0.1838342478
GSE13712_STATICUp0.0735223562
GSE19018Down-0.2087950692
GSE19899_A1Up0.0198327325
GSE19899_A2Down-0.0687846347
PubMed_21979375_A1Down-0.2038162341
PubMed_21979375_A2Up0.2445159783
GSE35957Down-0.2147434202
GSE36640Down-0.1630668610
GSE54402Up0.4573915550
GSE9593Down-0.1852962696
GSE43922Up0.0444788774
GSE24585Up0.2285559275
GSE37065Down-0.1494628389
GSE28863_A1Up0.1409353762
GSE28863_A2Up0.1726774989
GSE28863_A3Down-0.3648339414
GSE28863_A4Up0.0893870405
GSE48662Down-0.0054468299

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023858ProteomicsFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT032418ProteomicsFunctional MTI (Weak)18668040
hsa-miR-197-3pMIMAT0000227MIRT048057CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.