HCSGD entry for PLAT

1. General information

Official gene symbolPLAT
Entrez ID5327
Gene full nameplasminogen activator, tissue
Other gene symbolsT-PA TPA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0004252Serine-type endopeptidase activityIDA IEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0006508ProteolysisIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0014909Smooth muscle cell migrationIEAbiological_process
GO:0030141Secretory granuleIEAcellular_component
GO:0031012Extracellular matrixIDAcellular_component
GO:0031639Plasminogen activationIDAbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042730FibrinolysisTASbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045177Apical part of cellIEAcellular_component
GO:0045202SynapseIEAcellular_component
GO:0045861Negative regulation of proteolysisIDAbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayIEAbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0060279Positive regulation of ovulationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00020946010.95380556590.04208549621.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.2179335458
GSE13712_SHEARUp1.4603843556
GSE13712_STATICUp1.4969245397
GSE19018Up0.2896636889
GSE19899_A1Up0.0690244612
GSE19899_A2Up0.8867656661
PubMed_21979375_A1Up0.8562872555
PubMed_21979375_A2Up0.8920286337
GSE35957Up0.9836778355
GSE36640Up0.9476258972
GSE54402Down-0.4995502064
GSE9593Up1.1615510047
GSE43922Up0.9990380483
GSE24585Down-0.5793789160
GSE37065Up0.8875155486
GSE28863_A1Down-0.1004736969
GSE28863_A2Up1.0203673815
GSE28863_A3Down-0.1321699896
GSE28863_A4Up0.3971279590
GSE48662Up0.0718163820

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

UrokinaseDB00013 BTD00030 | BIOD00030
IloprostDB01088 APRD01027
5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACIDDB07684 -
C1 Esterase Inhibitor (Recombinant)DB09228 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-204-5pMIMAT0000265MIRT005838MicroarrayFunctional MTI (Weak)21282569
hsa-miR-21-5pMIMAT0000076MIRT005953Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI21131358
hsa-miR-335-5pMIMAT0000765MIRT017829MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25627976Furthermore, we defined tissue plasminogen activator (PLAT) as a critical direct target of miR340 for inhibition
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