HCSGD entry for PLA2G1B

1. General information

Official gene symbol	PLA2G1B
Entrez ID	5319
Gene full name	phospholipase A2, group IB (pancreas)
Other gene symbols	PLA2 PLA2A PPLA2
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000187	Activation of MAPK activity	ISS	biological_process
GO:0002446	Neutrophil mediated immunity	ISS	biological_process
GO:0004623	Phospholipase A2 activity	IDA IEA	molecular_function
GO:0005102	Receptor binding	IDA IEA IPI	molecular_function
GO:0005509	Calcium ion binding	IDA IEA	molecular_function
GO:0005576	Extracellular region	IEA TAS	cellular_component
GO:0005615	Extracellular space	IDA	cellular_component
GO:0006633	Fatty acid biosynthetic process	IDA IEA	biological_process
GO:0006644	Phospholipid metabolic process	IEA TAS	biological_process
GO:0006654	Phosphatidic acid biosynthetic process	TAS	biological_process
GO:0007015	Actin filament organization	TAS	biological_process
GO:0007165	Signal transduction	TAS	biological_process
GO:0009986	Cell surface	IDA IEA	cellular_component
GO:0010524	Positive regulation of calcium ion transport into cytosol	ISS	biological_process
GO:0015758	Glucose transport	ISS	biological_process
GO:0016042	Lipid catabolic process	IEA	biological_process
GO:0019370	Leukotriene biosynthetic process	ISS	biological_process
GO:0030141	Secretory granule	IEA	cellular_component
GO:0030593	Neutrophil chemotaxis	ISS	biological_process
GO:0032052	Bile acid binding	ISS	molecular_function
GO:0032431	Activation of phospholipase A2 activity	TAS	biological_process
GO:0032637	Interleukin-8 production	ISS	biological_process
GO:0032869	Cellular response to insulin stimulus	ISS	biological_process
GO:0035556	Intracellular signal transduction	ISS	biological_process
GO:0036148	Phosphatidylglycerol acyl-chain remodeling	TAS	biological_process
GO:0036149	Phosphatidylinositol acyl-chain remodeling	TAS	biological_process
GO:0036150	Phosphatidylserine acyl-chain remodeling	TAS	biological_process
GO:0036151	Phosphatidylcholine acyl-chain remodeling	TAS	biological_process
GO:0036152	Phosphatidylethanolamine acyl-chain remodeling	TAS	biological_process
GO:0044240	Multicellular organismal lipid catabolic process	IDA	biological_process
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0045740	Positive regulation of DNA replication	IDA IEA	biological_process
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	ISS	biological_process
GO:0046470	Phosphatidylcholine metabolic process	IDA	biological_process
GO:0046474	Glycerophospholipid biosynthetic process	TAS	biological_process
GO:0047498	Calcium-dependent phospholipase A2 activity	IDA IEA	molecular_function
GO:0048146	Positive regulation of fibroblast proliferation	IC	biological_process
GO:0050482	Arachidonic acid secretion	TAS	biological_process
GO:0050714	Positive regulation of protein secretion	TAS	biological_process
GO:0050778	Positive regulation of immune response	ISS	biological_process
GO:0051092	Positive regulation of NF-kappaB transcription factor activity	ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.2149839900	0.9151663349	0.8929451791	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.2171863917
GSE13712_SHEAR	Up	0.0314688597
GSE13712_STATIC	Up	0.5760030685
GSE19018	Up	0.1240468842
GSE19899_A1	Up	0.0103015074
GSE19899_A2	Down	-0.1515330530
PubMed_21979375_A1	Down	-0.0216787716
PubMed_21979375_A2	Down	-0.1369620042
GSE35957	Up	0.1261669036
GSE36640	Up	0.0102643920
GSE54402	Down	-0.0165604408
GSE9593	Up	0.3389845224
GSE43922	Up	0.0663222991
GSE24585	Up	0.0848785074
GSE37065	Down	-0.0615277006
GSE28863_A1	Up	0.1047586212
GSE28863_A2	Up	0.1868625673
GSE28863_A3	Up	0.2643868591
GSE28863_A4	Up	0.0106537614
GSE48662	Up	0.0510788018

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Hexane-1,6-Diol	DB02210	EXPT01731
N-Tridecanoic Acid	DB02448	EXPT03028
Cholic Acid	DB02659	EXPT00906
P-Anisic Acid	DB02795	EXPT00523
Heptanoic Acid	DB02938	EXPT02907
1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine	DB03565	EXPT01580
Pyruvoyl Group	DB03587	EXPT02707
Lpc-Ether	DB03633	EXPT02056
Niflumic Acid	DB04552	EXPT02331
PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER	DB07657	-
1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL	DB07836	-

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for PLA2G1B

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )