HCSGD entry for PKP2

1. General information

Official gene symbolPKP2
Entrez ID5318
Gene full nameplakophilin 2
Other gene symbolsARVD9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002159Desmosome assemblyIMPbiological_process
GO:0003674Molecular_functionNDmolecular_function
GO:0005080Protein kinase C bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusNAScellular_component
GO:0005882Intermediate filamentISScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionISScellular_component
GO:0005912Adherens junctionISScellular_component
GO:0007507Heart developmentISSbiological_process
GO:0008285Negative regulation of cell proliferationISSbiological_process
GO:0010765Positive regulation of sodium ion transportISSbiological_process
GO:0014704Intercalated discISScellular_component
GO:0016021Integral component of membraneTAScellular_component
GO:0016264Gap junction assemblyISSbiological_process
GO:0016337Cell-cell adhesionISS NASbiological_process
GO:0017080Sodium channel regulator activityISSmolecular_function
GO:0019215Intermediate filament bindingIDAmolecular_function
GO:0030057DesmosomeISS NAScellular_component
GO:0030336Negative regulation of cell migrationISSbiological_process
GO:0032947Protein complex scaffoldIMPmolecular_function
GO:0034334Adherens junction maintenanceISSbiological_process
GO:0044325Ion channel bindingISSmolecular_function
GO:0045110Intermediate filament bundle assemblyIMPbiological_process
GO:0048496Maintenance of organ identityIMPbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0055088Lipid homeostasisISSbiological_process
GO:0086001Cardiac muscle cell action potentialISSbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086019Cell-cell signaling involved in cardiac conductionIMPbiological_process
GO:0086064Cell communication by electrical coupling involved in cardiac conductionISSbiological_process
GO:0086069Bundle of His cell to Purkinje myocyte communicationIMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:2000810Regulation of tight junction assemblyISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12788986360.60763450100.72726817891.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4443012840
GSE13712_SHEARUp0.9813571571
GSE13712_STATICUp1.7842499810
GSE19018Up0.3156079166
GSE19899_A1Up0.0077899613
GSE19899_A2Up0.0453044300
PubMed_21979375_A1Up0.1382879579
PubMed_21979375_A2Down-0.0410261921
GSE35957Up0.1103686046
GSE36640Up0.1679138994
GSE54402Up0.1198034672
GSE9593Up0.1343518571
GSE43922Up0.0681990525
GSE24585Down-0.5445915481
GSE37065Down-0.1109662197
GSE28863_A1Down-0.1457378917
GSE28863_A2Down-0.1386780974
GSE28863_A3Up0.1778519085
GSE28863_A4Up0.0017311200
GSE48662Up0.1492812788

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT025489ProteomicsFunctional MTI (Weak)21566225
hsa-miR-744-5pMIMAT0004945MIRT037616CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT044957CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046783CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.