HCSGD entry for PKM

1. General information

Official gene symbolPKM
Entrez ID5315
Gene full namepyruvate kinase, muscle
Other gene symbolsCTHBP OIP3 PK3 PKM2 TCB THBP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0004743Pyruvate kinase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolNAS TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005929CiliumIEAcellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006096GlycolysisIEA TASbiological_process
GO:0012501Programmed cell deathIDAbiological_process
GO:0030955Potassium ion bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14225951900.65635471680.75710593701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0319088734
GSE13712_SHEARUp0.3279435726
GSE13712_STATICUp0.1705269759
GSE19018Up0.2440931065
GSE19899_A1Down-0.1165290631
GSE19899_A2Up0.5893966028
PubMed_21979375_A1Up0.7792561088
PubMed_21979375_A2Up1.3648411010
GSE35957Down-0.2947655021
GSE36640Down-0.0460908615
GSE54402Down-0.1879854228
GSE9593Down-0.0893974882
GSE43922Up0.0345436764
GSE24585Up0.0273758962
GSE37065Down-0.0226844526
GSE28863_A1Down-0.1493154398
GSE28863_A2Up0.2927825306
GSE28863_A3Down-0.4152799444
GSE28863_A4Up0.0000454037
GSE48662Up0.1363123698

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1085587CHEMBL10751899P14618
CHEMBL1509101CHEMBL10751899P14618
CHEMBL1089334CHEMBL10751899P14618
CHEMBL1939074CHEMBL10751899P14618
CHEMBL1358228CHEMBL10751899P14618
CHEMBL1939121CHEMBL10751899P14618
CHEMBL1939119CHEMBL10751899P14618
CHEMBL1938913CHEMBL10751899P14618
CHEMBL1939107CHEMBL10751899P14618
CHEMBL1939099CHEMBL10751899P14618
CHEMBL1939078CHEMBL10751899P14618
CHEMBL1938918CHEMBL10751899P14618
CHEMBL1939087CHEMBL10751899P14618
CHEMBL1939109CHEMBL10751899P14618
CHEMBL1939115CHEMBL10751899P14618
CHEMBL1939111CHEMBL10751899P14618
CHEMBL1939085CHEMBL10751899P14618
CHEMBL1939089CHEMBL10751899P14618
CHEMBL1939108CHEMBL10751899P14618
CHEMBL1938905CHEMBL10751899P14618
CHEMBL1939110CHEMBL10751899P14618
CHEMBL1939112CHEMBL10751899P14618
CHEMBL1938906CHEMBL10751899P14618
CHEMBL1311880CHEMBL10751899P14618
CHEMBL1939116CHEMBL10751899P14618
CHEMBL1376335CHEMBL10751899P14618
CHEMBL1938917CHEMBL10751899P14618
CHEMBL1939117CHEMBL10751899P14618
CHEMBL1939105CHEMBL10751899P14618
CHEMBL1939095CHEMBL10751899P14618
CHEMBL1938910CHEMBL10751899P14618
CHEMBL1514868CHEMBL10751899P14618
CHEMBL1939086CHEMBL10751899P14618
CHEMBL1939102CHEMBL10751899P14618
CHEMBL1938911CHEMBL10751899P14618
CHEMBL1939088CHEMBL10751899P14618
CHEMBL1938901CHEMBL10751899P14618
CHEMBL1938914CHEMBL10751899P14618
CHEMBL1939120CHEMBL10751899P14618
CHEMBL1939081CHEMBL10751899P14618
CHEMBL1939082CHEMBL10751899P14618
CHEMBL1938907CHEMBL10751899P14618
CHEMBL1939080CHEMBL10751899P14618
CHEMBL1939114CHEMBL10751899P14618
CHEMBL1938909CHEMBL10751899P14618
CHEMBL1939084CHEMBL10751899P14618
CHEMBL1939101CHEMBL10751899P14618
CHEMBL1939093CHEMBL10751899P14618
CHEMBL1939090CHEMBL10751899P14618
CHEMBL1939094CHEMBL10751899P14618
CHEMBL1938904CHEMBL10751899P14618
CHEMBL1939098CHEMBL10751899P14618
CHEMBL1397295CHEMBL10751899P14618
CHEMBL1939118CHEMBL10751899P14618
CHEMBL1938915CHEMBL10751899P14618
CHEMBL1939096CHEMBL10751899P14618
CHEMBL1377752CHEMBL10751899P14618
CHEMBL1939097CHEMBL10751899P14618
CHEMBL1877309CHEMBL10751899P14618
CHEMBL1939077CHEMBL10751899P14618
CHEMBL1938916CHEMBL10751899P14618
CHEMBL1939103CHEMBL10751899P14618
CHEMBL1413238CHEMBL10751899P14618
CHEMBL1938912CHEMBL10751899P14618
CHEMBL1939113CHEMBL10751899P14618
CHEMBL1939106CHEMBL10751899P14618
CHEMBL1939104CHEMBL10751899P14618
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  • Drugs

Name

Drug

Accession number

L-PhospholactateDB01733 EXPT02551
2-Phosphoglycolic AcidDB02726 EXPT02567 | DB02389
6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-oneDB07628 -
1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazineDB07692 -
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazineDB07697 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133bMIMAT0000770MIRT001815ImmunohistochemistryFunctional MTI (Weak)18464261
hsa-miR-133a-3pMIMAT0000427MIRT001816ImmunohistochemistryFunctional MTI (Weak)18464261
hsa-miR-326MIMAT0000756MIRT005520Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20667897
hsa-miR-326MIMAT0000756MIRT005520CLASHFunctional MTI (Weak)23622248
hsa-miR-122-5pMIMAT0000421MIRT023396MicroarrayFunctional MTI (Weak)17612493
hsa-miR-30a-5pMIMAT0000087MIRT028653ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1301-3pMIMAT0005797MIRT036045CLASHFunctional MTI (Weak)23622248
hsa-miR-935MIMAT0004978MIRT036697CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036965CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038155CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038436CLASHFunctional MTI (Weak)23622248
hsa-miR-766-3pMIMAT0003888MIRT039032CLASHFunctional MTI (Weak)23622248
hsa-miR-769-5pMIMAT0003886MIRT039183CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040961CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041665CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042646CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042876CLASHFunctional MTI (Weak)23622248
hsa-miR-328-3pMIMAT0000752MIRT043754CLASHFunctional MTI (Weak)23622248
hsa-miR-330-3pMIMAT0000751MIRT043843CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044585CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT046067CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046680CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046929CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047865CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049024CLASHFunctional MTI (Weak)23622248
hsa-miR-23a-3pMIMAT0000078MIRT050390CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052783CLASHFunctional MTI (Weak)23622248
hsa-miR-3187-3pMIMAT0015069MIRT052808CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-133bMIMAT0000770NAhsa-miR-133b{Western blot}{overexpression by miRNA precursor transfection}18464261
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18298799Here, we have shown that cytoplasmic PML (cPML) directly interacts with M2-type pyruvate kinase (PKM2), a key regulator of carbon fate
18298799PKM2 determines the proportion of carbons derived from glucose that are used for glycolytic energy production
18298799Over-expression of PML-2KA mutant in the cytoplasm, which was generated by mutagenesis of the nuclear localization signals of PML, in MCF-7 breast cancer cells suppressed PKM2 activity and the accumulation of lactate
18298799PKM2 exists in either an active tetrameric form which has high affinity for its substrate phosphoenolpyruvate (PEP) or a less active dimeric form which has low affinity for its substrate
18298799Over-expression of PML-2KA suppressed the activity of the tetrameric form of PKM2, but not the dimeric form
18298799Our findings suggest that cPML plays a role in tumor metabolism through its interaction with PKM2
15610763Other genes, such as Cdc28 protein kinase 1 (Cks1b), v-myb myeloblastosis viral oncogene homolog (MybL2), pyruvate kinase, muscle 2 (Pkm2) and Forkhead box M1 (FoxM1), were down-regulated only upon TGF-beta1 treatment but not by cellular senescence
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