HCSGD entry for PKD1

1. General information

Official gene symbolPKD1
Entrez ID5310
Gene full namepolycystic kidney disease 1 (autosomal dominant)
Other gene symbolsPBP Pc-1 TRPP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001502Cartilage condensationIEAbiological_process
GO:0001701In utero embryonic developmentISSbiological_process
GO:0001822Kidney developmentISSbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001892Embryonic placenta developmentISSbiological_process
GO:0002133Polycystin complexISScellular_component
GO:0005261Cation channel activityISSmolecular_function
GO:0005262Calcium channel activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005929CiliumISScellular_component
GO:0006611Protein export from nucleusISSbiological_process
GO:0006807Nitrogen compound metabolic processIEAbiological_process
GO:0007050Cell cycle arrestISSbiological_process
GO:0007156Homophilic cell adhesionTASbiological_process
GO:0007160Cell-matrix adhesionTASbiological_process
GO:0007161Calcium-independent cell-matrix adhesionTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007218Neuropeptide signaling pathwayIEAbiological_process
GO:0007259JAK-STAT cascadeISSbiological_process
GO:0007507Heart developmentIEPbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016328Lateral plasma membraneIEAcellular_component
GO:0018105Peptidyl-serine phosphorylationISSbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0021510Spinal cord developmentIEPbiological_process
GO:0021915Neural tube developmentIEPbiological_process
GO:0030246Carbohydrate bindingIEAmolecular_function
GO:0031512Motile primary ciliumISScellular_component
GO:0031659Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleIDAbiological_process
GO:0032092Positive regulation of protein bindingISSbiological_process
GO:0034220Ion transmembrane transportIBA ISSbiological_process
GO:0042994Cytoplasmic sequestering of transcription factorISSbiological_process
GO:0043588Skin developmentIEPbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048565Digestive tract developmentIEPbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIDAbiological_process
GO:0048806Genitalia developmentIEPbiological_process
GO:0050982Detection of mechanical stimulusIBA ISSbiological_process
GO:0051216Cartilage developmentIEPbiological_process
GO:0055085Transmembrane transportIBA ISSbiological_process
GO:0060236Regulation of mitotic spindle organizationIEAbiological_process
GO:0060428Lung epithelium developmentIEPbiological_process
GO:0060674Placenta blood vessel developmentISSbiological_process
GO:0061136Regulation of proteasomal protein catabolic processIDAbiological_process
GO:0070588Calcium ion transmembrane transportIBAbiological_process
GO:0072164Mesonephric tubule developmentIEPbiological_process
GO:0072177Mesonephric duct developmentIEPbiological_process
GO:0072205Metanephric collecting duct developmentIEPbiological_process
GO:0072218Metanephric ascending thin limb developmentIEPbiological_process
GO:0072237Metanephric proximal tubule developmentIEPbiological_process
GO:0072287Metanephric distal tubule morphogenesisIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03491244250.99707512250.42641781901.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0749463434
GSE28863_A2Down-0.0295988084
GSE28863_A3Up0.1877997599
GSE28863_A4Up0.2073953646
GSE48662Up1.1521795514

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT040353CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041636CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043090CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24828530Here, we identify protein kinase D1 (PKD1) as a downstream effector of ROS signaling to mediate Ras OIS and SASP
24828530PKD1 is activated by oncogenic Ras expression and PKD1 promotes Ras OIS by mediating inflammatory cytokines interleukin-6 (IL-6) and interleukin-8 (IL-8) via modulation of NF-kappaB activity
24828530In addition, ablation of PKD1 causes the bypass of Ras OIS, and promotes cell transformation and tumorigenesis
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