HCSGD entry for PITX3

1. General information

Official gene symbolPITX3
Entrez ID5309
Gene full namepaired-like homeodomain 3
Other gene symbolsCTPP4 CTRCT11 PTX3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002088Lens development in camera-type eyeISSbiological_process
GO:0002089Lens morphogenesis in camera-type eyeISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedISSbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0030901Midbrain developmentISSbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0048666Neuron developmentIEAbiological_process
GO:0070306Lens fiber cell differentiationIEAbiological_process
GO:0071542Dopaminergic neuron differentiationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36501078610.85819273580.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0248288074
GSE13712_SHEARDown-0.1387475413
GSE13712_STATICUp0.1101228217
GSE19018Up0.0462354348
GSE19899_A1Down-0.1266123341
GSE19899_A2Up0.1679909033
PubMed_21979375_A1Up0.0084350446
PubMed_21979375_A2Down-0.0333644017
GSE35957Up0.0819792409
GSE36640Up0.0741303214
GSE54402Down-0.0123684140
GSE9593Down-0.0294034017
GSE43922Up0.1553248118
GSE24585Up0.1411877021
GSE37065Down-0.0059127953
GSE28863_A1Down-0.1381729438
GSE28863_A2Up0.0558511060
GSE28863_A3Up0.3978625542
GSE28863_A4Up0.1667065161
GSE48662Up0.3083242088

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133bMIMAT0000770MIRT002354FACS//Luciferase reporter assayFunctional MTI17761882
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-133bMIMAT00007701hsa-miR-133b{Western blot}{Western blot}{overexpression by miRNA precursor transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}17761882
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.