HCSGD entry for PITX2

1. General information

Official gene symbolPITX2
Entrez ID5308
Gene full namepaired-like homeodomain 2
Other gene symbolsARP1 Brx1 IDG2 IGDS IGDS2 IHG2 IRID2 Otlx2 PTX2 RGS RIEG RIEG1 RS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0002074Extraocular skeletal muscle developmentIEAbiological_process
GO:0003171Atrioventricular valve developmentIEAbiological_process
GO:0003253Cardiac neural crest cell migration involved in outflow tract morphogenesisISSbiological_process
GO:0003350Pulmonary myocardium developmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007368Determination of left/right symmetryISSbiological_process
GO:0007520Myoblast fusionIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008584Male gonad developmentIEAbiological_process
GO:0008585Female gonad developmentIEAbiological_process
GO:0009725Response to hormoneIEAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0021763Subthalamic nucleus developmentIEAbiological_process
GO:0021855Hypothalamus cell migrationIEAbiological_process
GO:0030334Regulation of cell migrationIEAbiological_process
GO:0031076Embryonic camera-type eye developmentIEAbiological_process
GO:0031490Chromatin DNA bindingIEAmolecular_function
GO:0033189Response to vitamin AIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035315Hair cell differentiationICbiological_process
GO:0035886Vascular smooth muscle cell differentiationIEAbiological_process
GO:0035993Deltoid tuberosity developmentIMPbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042476OdontogenesisIMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043010Camera-type eye developmentIMPbiological_process
GO:0043021Ribonucleoprotein complex bindingICmolecular_function
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048536Spleen developmentISSbiological_process
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0051219Phosphoprotein bindingIPImolecular_function
GO:0055009Atrial cardiac muscle tissue morphogenesisIEAbiological_process
GO:0055015Ventricular cardiac muscle cell developmentIEAbiological_process
GO:0060126Somatotropin secreting cell differentiationTASbiological_process
GO:0060127Prolactin secreting cell differentiationTASbiological_process
GO:0060412Ventricular septum morphogenesisIEAbiological_process
GO:0060460Left lung morphogenesisIEAbiological_process
GO:0060577Pulmonary vein morphogenesisIEAbiological_process
GO:0060578Superior vena cava morphogenesisIEAbiological_process
GO:0061031Endodermal digestive tract morphogenesisIEAbiological_process
GO:0061072Iris morphogenesisIMPbiological_process
GO:0061325Cell proliferation involved in outflow tract morphogenesisISSbiological_process
GO:0070986Left/right axis specificationISSbiological_process
GO:2000288Positive regulation of myoblast proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45189533830.04488763720.99999024730.3985320742

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2907536005
GSE13712_SHEARDown-0.0043127615
GSE13712_STATICDown-0.0324893475
GSE19018Down-0.2152166757
GSE19899_A1Down-0.4351425420
GSE19899_A2Up0.7271857610
PubMed_21979375_A1Up0.7794799660
PubMed_21979375_A2Down-1.3102207375
GSE35957Down-0.9984326725
GSE36640Down-1.4315697203
GSE54402Up0.5560407660
GSE9593Down-0.8086960857
GSE43922Up0.0234194572
GSE24585Up0.0390402621
GSE37065Down-0.0998249577
GSE28863_A1Up0.0206986447
GSE28863_A2Down-0.0810384371
GSE28863_A3Down-0.0196753012
GSE28863_A4Up0.1699481034
GSE48662Up0.1705762437

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22829758These include COL4A3, CFLAR, GULP1, PDCD1, CASP10, PAX3, BOK, HSPD1, PITX2, and PML
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