HCSGD entry for PIM1
1. General information
| Official gene symbol | PIM1 |
|---|---|
| Entrez ID | 5292 |
| Gene full name | pim-1 oncogene |
| Other gene symbols | PIM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008283 | Cell proliferation | IDA | biological_process |
| GO:0030145 | Manganese ion binding | IDA | molecular_function |
| GO:0030212 | Hyaluronan metabolic process | IEA | biological_process |
| GO:0031659 | Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | IDA | biological_process |
| GO:0043024 | Ribosomal small subunit binding | IPI | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2666198017 | 0.0051838000 | 0.9624317933 | 0.1460320856 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7151334658 |
| GSE13712_SHEAR | Down | -0.5454081628 |
| GSE13712_STATIC | Down | -0.3033542369 |
| GSE19018 | Up | 1.0116792739 |
| GSE19899_A1 | Down | -0.1516676657 |
| GSE19899_A2 | Down | -1.1090801550 |
| PubMed_21979375_A1 | Down | -1.0096501303 |
| PubMed_21979375_A2 | Down | -0.9570950879 |
| GSE35957 | Down | -1.2900370092 |
| GSE36640 | Down | -2.8588627024 |
| GSE54402 | Down | -0.8817472242 |
| GSE9593 | Down | -0.0864350053 |
| GSE43922 | Down | -0.2528132776 |
| GSE24585 | Up | 0.3304459553 |
| GSE37065 | Down | -0.0883892704 |
| GSE28863_A1 | Up | 0.8579842978 |
| GSE28863_A2 | Up | 1.1093525908 |
| GSE28863_A3 | Up | 0.0246638950 |
| GSE28863_A4 | Down | -0.1213189267 |
| GSE48662 | Up | 0.2263579347 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One | DB01754 | EXPT02028 |
| Staurosporine | DB02010 | EXPT02970 | EXPT02972 |
| 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One | DB02656 | EXPT02073 |
| (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One | DB03650 | EXPT02029 |
| Rbt205 Inhibitor | DB03777 | EXPT00703 |
| Quercetin | DB04216 | EXPT02732 |
| Phosphoaminophosphonic Acid-Adenylate Ester | DB04395 | EXPT00524 |
| Phosphonoserine | DB04522 | EXPT02883 |
| S,S-(2-Hydroxyethyl)Thiocysteine | DB04530 | EXPT00954 |
| IMIDAZOPYRIDAZIN 1 | DB04715 | - |
| 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one | DB07151 | - |
| (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile | DB07242 | - |
| N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine | DB07524 | - |
| (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile | DB08022 | - |
| (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile | DB08166 | - |
| 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE | DB08230 | - |
| 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE | DB08705 | - |
| 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine | DB08707 | - |
| N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine | DB08708 | - |
| 2,3-diphenyl-1H-indole-7-carboxylic acid | DB08709 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT000151 | Luciferase reporter assay | Functional MTI | 19782034 |
| hsa-miR-1 | MIMAT0000416 | MIRT004322 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 18818206 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004857 | Luciferase reporter assay//qRT-PCR//Reporter assay;Microarray;Other | Functional MTI | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004857 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT006870 | Luciferase reporter assay | Functional MTI | 22970245 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017680 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024423 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028248 | Reporter assay | Functional MTI | 21743487 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | {Western blot} | {overexpression} | 21051663 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25040935 | Unexpectedly, we found that the expression of proto-oncogene PIM-1, which can promote tumorigenesis, is induced at transcriptional level during senescence |
| 25040935 | Inhibition of PIM-1 alleviated both replicative and oncogene-induced senescence |
| 25040935 | Conversely, ectopic expression of PIM-1 resulted in premature senescence |
| 25040935 | We also revealed that PIM-1 interacts with and phosphorylates heterochromatin protein 1gamma (HP1gamma) on Ser93 |
| 25040935 | Analysis of the mechanism underlying the up-regulation of PIM-1 expression during senescence demonstrated that IL-6, a critical regulator of cellular senescence, is responsible for PIM-1 induction |
| 25040935 | Analysis of the mechanism underlying the up-regulation of PIM-1 expression during senescence demonstrated that IL-6, a critical regulator of cellular senescence, is responsible for PIM-1 induction |
| 25040935 | Our study demonstrated that PIM-1 is a key component of the senescence machinery that contributes to heterochromatin formation |
| 25040935 | More importantly, we demonstrated that PIM-1 is also a direct target of IL-6/STAT3 signaling and mediates cytokine-induced cellular senescence |
| 20647331 | However, in a cell line-dependent manner, overexpression of PIM1 can inhibit cell and tumor growth |
| 20647331 | In 22Rv1 human prostate cells, but not in Du145 or RWPE-2, PIM1 overexpression was associated with marked increases in cellular senescence, as shown by changes in the levels of beta-galactosidase (SA-beta-Gal), p21, interleukin (IL)-6 and IL-8 mRNA and protein |
| 20647331 | Based on these results, PIM1 will have its most profound effects on tumorigenesis in situations where the senescence response is inactivated |
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