HCSGD entry for PIK3CA
1. General information
| Official gene symbol | PIK3CA |
|---|---|
| Entrez ID | 5290 |
| Gene full name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Other gene symbols | CLOVE CWS5 MCAP MCM MCMTC PI3K p110-alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001944 | Vasculature development | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IBA | cellular_component |
| GO:0005942 | Phosphatidylinositol 3-kinase complex | IEA ISS | cellular_component |
| GO:0005943 | 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex | IDA | cellular_component |
| GO:0006006 | Glucose metabolic process | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IEA | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006661 | Phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0016301 | Kinase activity | TAS | molecular_function |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | IDA IEA | molecular_function |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030295 | Protein kinase activator activity | IEA | molecular_function |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0035004 | Phosphatidylinositol 3-kinase activity | ISS TAS | molecular_function |
| GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity | IBA | molecular_function |
| GO:0036092 | Phosphatidylinositol-3-phosphate biosynthetic process | IDA | biological_process |
| GO:0038028 | Insulin receptor signaling pathway via phosphatidylinositol 3-kinase | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0040014 | Regulation of multicellular organism growth | IEA | biological_process |
| GO:0043491 | Protein kinase B signaling | IEA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043542 | Endothelial cell migration | TAS | biological_process |
| GO:0043560 | Insulin receptor substrate binding | IEA | molecular_function |
| GO:0044029 | Hypomethylation of CpG island | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046854 | Phosphatidylinositol phosphorylation | ISS | biological_process |
| GO:0046934 | Phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | IEA TAS | biological_process |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0060048 | Cardiac muscle contraction | TAS | biological_process |
| GO:2000270 | Negative regulation of fibroblast apoptotic process | IEA | biological_process |
| GO:2000653 | Regulation of genetic imprinting | IEA | biological_process |
| GO:2000811 | Negative regulation of anoikis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1190089624 | 0.4612886592 | 0.7070870684 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0706413366 |
| GSE13712_SHEAR | Down | -0.0097756225 |
| GSE13712_STATIC | Down | -0.0689302093 |
| GSE19018 | Up | 0.3505954284 |
| GSE19899_A1 | Up | 0.1957838412 |
| GSE19899_A2 | Down | -0.0718859833 |
| PubMed_21979375_A1 | Up | 0.1601688353 |
| PubMed_21979375_A2 | Up | 0.0883412992 |
| GSE35957 | Up | 0.4248162358 |
| GSE36640 | Up | 0.6043718334 |
| GSE54402 | Up | 0.3386874102 |
| GSE9593 | Up | 0.2373105350 |
| GSE43922 | Down | -0.0236050000 |
| GSE24585 | Up | 0.4025997755 |
| GSE37065 | Down | -0.1512599145 |
| GSE28863_A1 | Up | 0.1969394956 |
| GSE28863_A2 | Down | -0.0043791926 |
| GSE28863_A3 | Down | -0.6151978587 |
| GSE28863_A4 | Down | -0.0871577639 |
| GSE48662 | Down | -0.5613215645 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| XL147 | DB05240 | - |
| XL765 | DB05241 | - |
| (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | DB08059 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT007316 | Western blot | Functional MTI | 23238785 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017306 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050839 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23174937 | Gly12Asp mutations were detected in eight tumors (six serous and two mucinous), BRAF V600E mutations in two serous tumors, and PIK3CA H1047Y and PIK3CA E542K mutations in a serous and an endometrioid BOT, respectively |
| 22120720 | Activation of the PI-3-kinase pathway by introduction of mutant, oncogenic PIK3CA into breast mammary epithelial cells increased both the expression and activation of PKCiota |
| 21909130 | Furthermore, our data imply that chronic activation of AKT signalling provides selective pressure for the loss of p53 function, consistent with observations that PTEN or PIK3CA mutations are significantly associated with p53 mutation in a number of human tumour types |
| 21256021 | Consistent with this, we show that oncogenic mutations in p110alpha (H1047R and E545K) partially evade this negative regulation, resulting in increased AKT activity in the population |
| 19723919 | Cox proportional hazard models computed hazard ratio (HR) for death, adjusted for potential confounders, including p53, cyclin D1, KRAS, BRAF, PIK3CA, LINE-1 hypomethylation, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) |
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