HCSGD entry for SERPINA1
1. General information
| Official gene symbol | SERPINA1 |
|---|---|
| Entrez ID | 5265 |
| Gene full name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
| Other gene symbols | A1A A1AT AAT PI PI1 PRO2275 alpha1AT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002020 | Protease binding | IPI | molecular_function |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA IEA IMP | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0006953 | Acute-phase response | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0030162 | Regulation of proteolysis | IBA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0077031192 | 0.9520339273 | 0.2280695163 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0450350299 |
| GSE13712_SHEAR | Down | -0.0026163508 |
| GSE13712_STATIC | Down | -0.0036888568 |
| GSE19018 | Up | 0.3556030751 |
| GSE19899_A1 | Up | 0.4719187344 |
| GSE19899_A2 | Up | 1.2986926893 |
| PubMed_21979375_A1 | Up | 1.8160193502 |
| PubMed_21979375_A2 | Up | 1.2820989434 |
| GSE35957 | Up | 0.1724568339 |
| GSE36640 | Down | -0.0121573504 |
| GSE54402 | Up | 1.8698561544 |
| GSE9593 | Up | 0.2819379002 |
| GSE43922 | Up | 0.7350436393 |
| GSE24585 | Down | -0.1133587664 |
| GSE37065 | Down | -0.2246628744 |
| GSE28863_A1 | Down | -0.0797379298 |
| GSE28863_A2 | Down | -0.0740724985 |
| GSE28863_A3 | Up | 0.3689285072 |
| GSE28863_A4 | Down | -0.1531260668 |
| GSE48662 | Up | 0.0403775250 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol | DB01998 | EXPT02980 |
| Beta-Mercaptoethanol | DB03345 | EXPT02882 | DB03131 |
| Recombinant alpha 1-antitrypsin | DB05481 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016814 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25341065 | RATIONALE: alpha1-Antitrypsin (A1AT) was identified as a plasma protease inhibitor; however, it is now recognized as a multifunctional protein that modulates immunity, inflammation, proteostasis, apoptosis, and cellular senescence |
| 25341065 | Like A1AT, protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, regulates similar biologic processes and plays a key role in chronic obstructive pulmonary disease |
| 25341065 | OBJECTIVES: Given their common effects, this study investigated whether A1AT acts via PP2A to alter tumor necrosis factor (TNF) signaling, inflammation, and proteolytic responses in this disease |
| 25341065 | PP2A activation was assessed in human neutrophils, airway epithelial cells, and peripheral blood monocytes treated with plasma purified A1AT protein |
| 25341065 | Similarly, lung PP2A activity was measured in mice administered intranasal A1AT |
| 25341065 | PP2A was silenced in lung epithelial cells treated with A1AT and matrix metalloproteinase and cytokine production was then measured following TNF-alpha stimulation |
| 25341065 | A1AT protein activated PP2A in human alveolar macrophages, monocytes, neutrophils, airway epithelial cells, and in mouse lungs |
| 25341065 | This activation required functionally active A1AT protein and protein tyrosine phosphatase 1B expression |
| 25341065 | CONCLUSIONS: Together, these data indicate that A1AT modulates PP2A to counter inflammatory and proteolytic responses induced by TNF signaling in the lung |
| 22697349 | Systemic deficiency in AAT (AATD) due to genetic mutations can result in liver failure and chronic lung disease such as emphysema |
| 22697349 | Over the past decade, however, investigations of AATD have described multiple functions of AAT beyond those generally attributed to its antiprotease activity |
| 22697349 | Evidence now suggests that AAT plays an important role in modulating immunity, inflammation, proteostasis, apoptosis, and possibly cellular senescence programs |
| 22697349 | Finally, we consider the data regarding treatment of AATD, including AAT supplementation and its current limitations, and suggest further avenues of research informed by the multiple functions of AAT |
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