HCSGD entry for ATP6V1B2
1. General information
| Official gene symbol | ATP6V1B2 |
|---|---|
| Entrez ID | 526 |
| Gene full name | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 |
| Other gene symbols | ATP6B1B2 ATP6B2 HO57 VATB VPP3 Vma2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | ISS TAS | cellular_component |
| GO:0005886 | Plasma membrane | ISS | cellular_component |
| GO:0005902 | Microvillus | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0015078 | Hydrogen ion transmembrane transporter activity | TAS | molecular_function |
| GO:0015991 | ATP hydrolysis coupled proton transport | IEA | biological_process |
| GO:0015992 | Proton transport | IEA TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016820 | Hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | IEA | molecular_function |
| GO:0033178 | Proton-transporting two-sector ATPase complex, catalytic domain | IEA | cellular_component |
| GO:0033180 | Proton-transporting V-type ATPase, V1 domain | IEA | cellular_component |
| GO:0033572 | Transferrin transport | TAS | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046034 | ATP metabolic process | IEA | biological_process |
| GO:0046961 | Proton-transporting ATPase activity, rotational mechanism | TAS | molecular_function |
| GO:0051701 | Interaction with host | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0090382 | Phagosome maturation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0014038334 | 0.9828763725 | 0.1010823848 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.2191966594 |
| GSE13712_SHEAR | Up | 0.1719181343 |
| GSE13712_STATIC | Up | 0.4081355388 |
| GSE19018 | Down | -0.0633016673 |
| GSE19899_A1 | Up | 1.5123871820 |
| GSE19899_A2 | Up | 1.2624349077 |
| PubMed_21979375_A1 | Up | 1.6576212378 |
| PubMed_21979375_A2 | Up | 2.5446980169 |
| GSE35957 | Up | 0.0524738634 |
| GSE36640 | Down | -0.0934641154 |
| GSE54402 | Up | 0.8283236926 |
| GSE9593 | Up | 0.9308629987 |
| GSE43922 | Up | 0.7676102762 |
| GSE24585 | Up | 0.2260626693 |
| GSE37065 | Up | 0.3277422497 |
| GSE28863_A1 | Up | 0.0662885257 |
| GSE28863_A2 | Up | 0.3154613477 |
| GSE28863_A3 | Down | -0.3178986182 |
| GSE28863_A4 | Down | -0.2085825018 |
| GSE48662 | Down | -0.2793496317 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Gallium nitrate | DB05260 | - |
| 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE | DB07347 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT003524 | Luciferase reporter assay | Functional MTI | 20144220 |
| hsa-miR-1 | MIMAT0000416 | MIRT003524 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT003524 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028603 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031775 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037045 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-3p | MIMAT0004602 | MIRT038644 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041130 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044823 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048184 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052366 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 20144220 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
