HCSGD entry for PHEX
1. General information
| Official gene symbol | PHEX |
|---|---|
| Entrez ID | 5251 |
| Gene full name | phosphate regulating endopeptidase homolog, X-linked |
| Other gene symbols | HPDR HPDR1 HYP HYP1 LXHR PEX XLH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0004177 | Aminopeptidase activity | IEA | molecular_function |
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006508 | Proteolysis | IDA IEA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0019637 | Organophosphate metabolic process | IEA | biological_process |
| GO:0030282 | Bone mineralization | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1080005737 | 0.7585627142 | 0.6821991365 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0789171023 |
| GSE13712_SHEAR | Down | -0.0340965026 |
| GSE13712_STATIC | Up | 0.2358182208 |
| GSE19018 | Up | 0.0271734744 |
| GSE19899_A1 | Up | 0.1403544834 |
| GSE19899_A2 | Up | 0.0812959796 |
| PubMed_21979375_A1 | Up | 0.4319876410 |
| PubMed_21979375_A2 | Up | 0.3075681389 |
| GSE35957 | Up | 0.0509896637 |
| GSE36640 | Up | 0.1421532742 |
| GSE54402 | Up | 0.1181557998 |
| GSE9593 | Up | 1.3531019361 |
| GSE43922 | Up | 0.0132977262 |
| GSE24585 | Down | -0.6061385846 |
| GSE37065 | Up | 0.1406863078 |
| GSE28863_A1 | Up | 0.4693379064 |
| GSE28863_A2 | Up | 0.2065064571 |
| GSE28863_A3 | Down | -0.3043662758 |
| GSE28863_A4 | Down | -0.1242393863 |
| GSE48662 | Down | -0.1119591944 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT051061 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17961760 | To make such a method comparable to other methods of collagen determination, we calibrated a colorimetric procedure both by hydroxyproline (HYP) determinations and in terms of collagen concentration |
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