HCSGD entry for ABCB4

1. General information

Official gene symbolABCB4
Entrez ID5244
Gene full nameATP-binding cassette, sub-family B (MDR/TAP), member 4
Other gene symbolsABC21 GBD1 ICP3 MDR2 MDR2/3 MDR3 PFIC-3 PGY3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIBAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006200ATP catabolic processIBA TASbiological_process
GO:0006629Lipid metabolic processTASbiological_process
GO:0006810TransportTASbiological_process
GO:0008559Xenobiotic-transporting ATPase activityIEAmolecular_function
GO:0016020MembraneIEA TAScellular_component
GO:0016021Integral component of membraneIBAcellular_component
GO:0016324Apical plasma membraneIBAcellular_component
GO:0042493Response to drugTASbiological_process
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIBAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046581Intercellular canaliculusIBA IEAcellular_component
GO:0055085Transmembrane transportIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33635363400.89460336230.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0437478101
GSE13712_SHEARUp0.0236567141
GSE13712_STATICDown-0.1102866467
GSE19018Up0.1818509260
GSE19899_A1Up0.1531075051
GSE19899_A2Down-0.1813993785
PubMed_21979375_A1Up0.1016870316
PubMed_21979375_A2Down-0.0429785953
GSE35957Down-0.2558951288
GSE36640Up0.2291679411
GSE54402Up0.0476612261
GSE9593Up0.0699229225
GSE43922Up0.0157532991
GSE24585Up0.8879711704
GSE37065Down-0.0682363388
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0376337556

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.