HCSGD entry for ABCB1

1. General information

Official gene symbolABCB1
Entrez ID5243
Gene full nameATP-binding cassette, sub-family B (MDR/TAP), member 1
Other gene symbolsABC20 CD243 CLCS GP170 MDR1 P-GP PGY1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleIDAbiological_process
GO:0000139Golgi membraneIBAcellular_component
GO:0005215Transporter activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006200ATP catabolic processIBA TASbiological_process
GO:0006810TransportTASbiological_process
GO:0006855Drug transmembrane transportTASbiological_process
GO:0008559Xenobiotic-transporting ATPase activityIEAmolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIBA IEAcellular_component
GO:0016324Apical plasma membraneIBAcellular_component
GO:0042493Response to drugTASbiological_process
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIBA IEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046581Intercellular canaliculusIBAcellular_component
GO:0055085Transmembrane transportIBA TASbiological_process
GO:0072089Stem cell proliferationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06016478100.89602829300.53199439411.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0193012765
GSE13712_SHEARUp0.6342580305
GSE13712_STATICUp0.1064884844
GSE19018Down-0.0134534778
GSE19899_A1Up0.2249721928
GSE19899_A2Down-0.3275468042
PubMed_21979375_A1Up0.2491254715
PubMed_21979375_A2Up0.3256552359
GSE35957Up0.0319000748
GSE36640Up2.7473289486
GSE54402Up0.0551880873
GSE9593Up0.1471513037
GSE43922Up0.0244907202
GSE24585Up0.1027088936
GSE37065Up0.0826883950
GSE28863_A1Down-0.4620195173
GSE28863_A2Up0.4042646463
GSE28863_A3Up0.1577129387
GSE28863_A4Down-0.0372530855
GSE48662Up0.0450537737

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
RoxithromycinDB00778 APRD01305
VoacamineDB04877 -
ElacridarDB04881 -
TesmilifeneDB04905 -
FM-VP4DB05449 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-451aMIMAT0001631MIRT005656qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18645025
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-451aMIMAT0001631NAhsa-miR-45118645025
hsa-miR-296-5pMIMAT0000690NAhsa-miR-296-5p{Western blot}{downregulation}20485139
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23174937Potentially functional polymorphisms were found in vascular endothelial growth factor (VEGF), ABCB1, FGFR2 and PHLPP2
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