HCSGD entry for PGR
1. General information
| Official gene symbol | PGR |
|---|---|
| Entrez ID | 5241 |
| Gene full name | progesterone receptor |
| Other gene symbols | NR3C3 PR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001542 | Ovulation from ovarian follicle | IEA | biological_process |
| GO:0002070 | Epithelial cell maturation | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005496 | Steroid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IEA | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEP | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0050678 | Regulation of epithelial cell proliferation | IEA | biological_process |
| GO:0050847 | Progesterone receptor signaling pathway | IEA | biological_process |
| GO:0060748 | Tertiary branching involved in mammary gland duct morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7542737586 | 0.7892244938 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0070887943 |
| GSE13712_SHEAR | Up | 0.0198106907 |
| GSE13712_STATIC | Down | -0.0782333793 |
| GSE19018 | Up | 0.1992612799 |
| GSE19899_A1 | Up | 0.0615786173 |
| GSE19899_A2 | Up | 0.1411077518 |
| PubMed_21979375_A1 | Up | 0.0823546533 |
| PubMed_21979375_A2 | Down | -0.0791088152 |
| GSE35957 | Up | 0.2321651822 |
| GSE36640 | Down | -0.0085568048 |
| GSE54402 | Up | 0.1321304657 |
| GSE9593 | Up | 0.0193770452 |
| GSE43922 | Up | 0.0489333928 |
| GSE24585 | Down | -0.1790033071 |
| GSE37065 | Up | 0.0514456140 |
| GSE28863_A1 | Down | -0.3149870080 |
| GSE28863_A2 | Up | 0.1057170500 |
| GSE28863_A3 | Up | 0.1117310012 |
| GSE28863_A4 | Down | -0.0072254046 |
| GSE48662 | Down | -0.1059023340 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Etonogestrel | DB00294 | APRD00766 |
| Desogestrel | DB00304 | APRD00762 |
| Spironolactone | DB00421 | APRD01234 |
| Fluticasone Propionate | DB00588 | APRD00065 |
| Mifepristone | DB00834 | APRD00432 |
| Drospirenone | DB01395 | - |
| Danazol | DB01406 | - |
| Allylestrenol | DB01431 | - |
| Methyltrienolone | DB02998 | EXPT02741 |
| Tanaproget | DB04787 | - |
| Proellex | DB05253 | - |
| Norelgestromin | DB06713 | - |
| Hydroxyprogesterone caproate | DB06789 | - |
| Ulipristal | DB08867 | DB05366 |
| Norgestrel | DB09389 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-126-3p | MIMAT0000445 | MIRT021282 | Reporter assay;Western blot | Functional MTI | 21526342 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26577046 | Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming |
| 26577046 | Herein, it is demonstrated, using progesterone receptor (PR) isoform-specific ovarian cancer model systems, that PR-A and PR-B promote distinct gene expression profiles that differ from PR-driven genes in breast cancer cells |
| 24112790 | Furthermore, in kisspeptin neurons, the expression of estrogen receptor alpha (ERalpha), but not progesterone receptor (PR), decreased with age |
| 23178160 | Progestin drives breast cancer growth by inducing p21(CIP1) expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2 |
| 23178160 | Interestingly, we determined that progestin drives p21(CIP1) transcriptional activation via a novel nonclassical transcriptional mechanism in which progesterone receptor is recruited along with Stat3 and ErbB-2 to a Stat3 binding site at p21(CIP1) promoter |
| 22353808 | These cells expressed progesterone receptor B and showed significant growth inhibition by various progestins |
| 21627565 | MATERIALS AND METHODS: In 50 breast cancer tissue samples hTERT mRNA expression and TA were correlated with cell features (HER2, Estrogen and Progesterone Receptor status) |
| 12835295 | METHODS: p33(ING1b), p53, oestrogen receptor (ER), and progesterone receptor (PgR) expression was studied in 86 primary invasive breast cancers using immunohistochemistry |
| 12835295 | Analysis of several known biological factors indicated that high grade tumours were of larger size and more often negative for ER and PgR expression |
| 12835295 | Positive correlations were found between nuclear p33(ING1b) expression and both ER and PgR expression |
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