HCSGD entry for ATP6V1A
1. General information
| Official gene symbol | ATP6V1A |
|---|---|
| Entrez ID | 523 |
| Gene full name | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A |
| Other gene symbols | ATP6A1 ATP6V1A1 HO68 VA68 VPP2 Vma1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA ISS TAS | cellular_component |
| GO:0005886 | Plasma membrane | ISS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005902 | Microvillus | IEA | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0015991 | ATP hydrolysis coupled proton transport | IEA | biological_process |
| GO:0015992 | Proton transport | IEA | biological_process |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0016469 | Proton-transporting two-sector ATPase complex | TAS | cellular_component |
| GO:0033180 | Proton-transporting V-type ATPase, V1 domain | IEA | cellular_component |
| GO:0033572 | Transferrin transport | TAS | biological_process |
| GO:0046034 | ATP metabolic process | IEA | biological_process |
| GO:0046961 | Proton-transporting ATPase activity, rotational mechanism | IEA | molecular_function |
| GO:0051701 | Interaction with host | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0090382 | Phagosome maturation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0152456632 | 0.6152524106 | 0.3074950958 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8316508252 |
| GSE13712_SHEAR | Down | -0.1577731807 |
| GSE13712_STATIC | Down | -0.2640390469 |
| GSE19018 | Up | 0.1445506719 |
| GSE19899_A1 | Up | 0.2492956753 |
| GSE19899_A2 | Up | 0.4168238242 |
| PubMed_21979375_A1 | Down | -0.0192654144 |
| PubMed_21979375_A2 | Up | 0.4856722407 |
| GSE35957 | Up | 0.5076473113 |
| GSE36640 | Up | 1.1822331828 |
| GSE54402 | Down | -0.0038201773 |
| GSE9593 | Up | 1.3384866976 |
| GSE43922 | Up | 0.3053038344 |
| GSE24585 | Up | 0.6788603841 |
| GSE37065 | Up | 0.3948814042 |
| GSE28863_A1 | Down | -0.5231057503 |
| GSE28863_A2 | Down | -0.0635061406 |
| GSE28863_A3 | Down | -0.3563993168 |
| GSE28863_A4 | Down | -0.3800549536 |
| GSE48662 | Down | -0.2550915431 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Alendronic acid | DB00630 | APRD00561 |
| Tiludronate | DB01133 | APRD01259 |
| Bafilomycin A1 | DB06733 | - |
| Bafilomycin B1 | DB06734 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023734 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029234 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044054 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
