HCSGD entry for PGD
1. General information
| Official gene symbol | PGD |
|---|---|
| Entrez ID | 5226 |
| Gene full name | phosphogluconate dehydrogenase |
| Other gene symbols | 6PGD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004616 | Phosphogluconate dehydrogenase (decarboxylating) activity | EXP IEA ISS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006098 | Pentose-phosphate shunt | IEA ISS TAS | biological_process |
| GO:0009051 | Pentose-phosphate shunt, oxidative branch | IDA | biological_process |
| GO:0019322 | Pentose biosynthetic process | IEA | biological_process |
| GO:0019521 | D-gluconate metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050661 | NADP binding | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5010669579 | 0.3752147525 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6224214920 |
| GSE13712_SHEAR | Down | -0.0119354433 |
| GSE13712_STATIC | Down | -0.1346312400 |
| GSE19018 | Down | -0.3084439393 |
| GSE19899_A1 | Down | -0.0584714166 |
| GSE19899_A2 | Up | 0.0627618059 |
| PubMed_21979375_A1 | Up | 0.0264489515 |
| PubMed_21979375_A2 | Down | -0.1926517851 |
| GSE35957 | Down | -0.2716827704 |
| GSE36640 | Up | 0.2235390570 |
| GSE54402 | Up | 0.1551465647 |
| GSE9593 | Up | 0.0206135677 |
| GSE43922 | Up | 0.0849027069 |
| GSE24585 | Up | 0.0082825267 |
| GSE37065 | Down | -0.2258553825 |
| GSE28863_A1 | Up | 0.0647599844 |
| GSE28863_A2 | Up | 0.1115505552 |
| GSE28863_A3 | Down | -0.5584466800 |
| GSE28863_A4 | Down | -0.0628552728 |
| GSE48662 | Up | 0.3309208725 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Gadopentetate dimeglumine | DB00789 | APRD00991 |
| Ketotifen | DB00920 | APRD01061 |
| 6-Phosphogluconic Acid | DB02076 | EXPT00290 |
| Nicotinamide 8-Bromo-Adenine Dinucleotide Phosphate | DB03962 | EXPT02303 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023542 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-484 | MIMAT0002174 | MIRT042195 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042801 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046414 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047325 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051576 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24096100 | Evidence for dimer/tetramer equilibrium in Trypanosoma brucei 6-phosphogluconate dehydrogenase |
| 24096100 | 6-Phosphogluconate dehydrogenase (6PGDH), the third enzyme of the pentose phosphate pathway (PPP), is essential for biosyntheses and oxidative stress defence |
| 1764909 | The activities of six enzymes: glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD), hexokinase (Hx), glutamate oxaloacetate transminase (GOT), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE), were measured in the red cells of different ages which were obtained either by centrifugation or experimental anaemia |
| 1756776 | Eight enzyme loci (G6PD, PGM1, PGM3, PepA, PGD, ADA, GLO1, and ME), proved to be informative in establishing unique allozyme genetic signatures for all of the cell strains established from the same species and from the same organ |
| 1666816 | These procedures have been used to monitor the decline of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activity during the process of red cell aging in normal subjects and in beta-thal carriers, to study transfused patients with G6PD and pyruvate kinase (PK) deficiency and to test the effects of inositol hexaphosphate (IHP) encapsulation on RBC subpopulations |
| 3757268 | The enzyme activities of glucose-6-phosphate dehydrogenase (G6PD), 6-phospho-gluconate dehydrogenase (6PGD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were measured in normal human red cells separated centrifugally in a discontinuous density gradient of Percoll |
| 1251580 | In ageing rat erythrocytes the activities of HK, GR and 6-PGD did not fall below the normal range during the first 9 tenths of the potential life-span |
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