HCSGD entry for PFKL
1. General information
| Official gene symbol | PFKL |
|---|---|
| Entrez ID | 5211 |
| Gene full name | phosphofructokinase, liver |
| Other gene symbols | PFK-B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003872 | 6-phosphofructokinase activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005945 | 6-phosphofructokinase complex | IDA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006002 | Fructose 6-phosphate metabolic process | IDA IMP | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006096 | Glycolysis | IDA IEA TAS | biological_process |
| GO:0009749 | Response to glucose | IDA | biological_process |
| GO:0019900 | Kinase binding | IPI | molecular_function |
| GO:0030388 | Fructose 1,6-bisphosphate metabolic process | IDA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046676 | Negative regulation of insulin secretion | IEA | biological_process |
| GO:0046835 | Carbohydrate phosphorylation | IDA IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051259 | Protein oligomerization | IDA | biological_process |
| GO:0051289 | Protein homotetramerization | IEA | biological_process |
| GO:0070061 | Fructose binding | IDA | molecular_function |
| GO:0070095 | Fructose-6-phosphate binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4542788230 | 0.1928345466 | 0.9999902473 | 0.8514675558 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6852074720 |
| GSE13712_SHEAR | Down | -0.0926292139 |
| GSE13712_STATIC | Down | -0.3204178809 |
| GSE19018 | Up | 0.4235220136 |
| GSE19899_A1 | Down | -0.3814978951 |
| GSE19899_A2 | Down | -0.1974247478 |
| PubMed_21979375_A1 | Up | 0.0469326657 |
| PubMed_21979375_A2 | Up | 0.0607018495 |
| GSE35957 | Down | -0.2260858400 |
| GSE36640 | Down | -0.1985413212 |
| GSE54402 | Up | 0.1089926090 |
| GSE9593 | Up | 0.1452938833 |
| GSE43922 | Down | -0.2107041641 |
| GSE24585 | Down | -0.0087127740 |
| GSE37065 | Down | -0.1036234097 |
| GSE28863_A1 | Up | 0.1364771255 |
| GSE28863_A2 | Up | 0.4577677713 |
| GSE28863_A3 | Down | -0.1131783015 |
| GSE28863_A4 | Down | -0.0610094874 |
| GSE48662 | Up | 0.9042010767 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036473 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-330-5p | MIMAT0004693 | MIRT038234 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042383 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042578 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045672 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
