HCSGD entry for PFKFB4

1. General information

Official gene symbolPFKFB4
Entrez ID5210
Gene full name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00038736-phosphofructo-2-kinase activityIEA NASmolecular_function
GO:0004331Fructose-2,6-bisphosphate 2-phosphatase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006000Fructose metabolic processIEAbiological_process
GO:0006003Fructose 2,6-bisphosphate metabolic processIEAbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006096GlycolysisTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046835Carbohydrate phosphorylationNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06323164770.06518951030.54299638670.4821166339

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3848620675
GSE13712_SHEARDown-0.2308481824
GSE13712_STATICDown-0.0029709630
GSE19018Up0.8655070553
GSE19899_A1Up0.3353779336
GSE19899_A2Up0.1947090653
PubMed_21979375_A1Up0.2972582302
PubMed_21979375_A2Up0.3822591119
GSE35957Down-0.6830869404
GSE36640Down-0.4510080567
GSE54402Up0.5589544405
GSE9593Up0.0083757727
GSE43922Up0.0858378147
GSE24585Down-0.0151684301
GSE37065Up0.4335133911
GSE28863_A1Down-0.5558491230
GSE28863_A2Up0.5962521428
GSE28863_A3Down-0.9509249076
GSE28863_A4Down-0.7444428978
GSE48662Up0.7286102926

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
Fructose-6-PhosphateDB04493 EXPT01383

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016861MicroarrayFunctional MTI (Weak)18185580
hsa-miR-92b-3pMIMAT0003218MIRT040714CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.