HCSGD entry for PFAS
1. General information
| Official gene symbol | PFAS |
|---|---|
| Entrez ID | 5198 |
| Gene full name | phosphoribosylformylglycinamidine synthase |
| Other gene symbols | FGAMS FGARAT PURL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004642 | Phosphoribosylformylglycinamidine synthase activity | IDA IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006189 | 'de novo' IMP biosynthetic process | IEA NAS | biological_process |
| GO:0006541 | Glutamine metabolic process | IEA | biological_process |
| GO:0009156 | Ribonucleoside monophosphate biosynthetic process | IEA | biological_process |
| GO:0009168 | Purine ribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9879664146 | 0.0004321606 | 0.9999902473 | 0.0385589831 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3676772138 |
| GSE13712_SHEAR | Down | -0.2775141732 |
| GSE13712_STATIC | Up | 0.0293287217 |
| GSE19018 | Down | -2.2253498542 |
| GSE19899_A1 | Down | -0.8565558145 |
| GSE19899_A2 | Down | -1.1069993390 |
| PubMed_21979375_A1 | Down | -0.9383020367 |
| PubMed_21979375_A2 | Down | -1.3692442429 |
| GSE35957 | Down | -1.5616431533 |
| GSE36640 | Down | -2.1992192742 |
| GSE54402 | Down | -0.2442764019 |
| GSE9593 | Down | -1.3666573021 |
| GSE43922 | Down | -0.2987852171 |
| GSE24585 | Down | -0.9451323708 |
| GSE37065 | Down | -0.3963662123 |
| GSE28863_A1 | Up | 0.3187023092 |
| GSE28863_A2 | Up | 0.1237064175 |
| GSE28863_A3 | Up | 0.2444043802 |
| GSE28863_A4 | Up | 0.1434665579 |
| GSE48662 | Down | -0.2730003543 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-330-5p | MIMAT0004693 | MIRT038233 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-3p | MIMAT0004602 | MIRT038636 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043096 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047471 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047554 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048110 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048843 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT050032 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051541 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
