HCSGD entry for PEX6
1. General information
| Official gene symbol | PEX6 |
|---|---|
| Entrez ID | 5190 |
| Gene full name | peroxisomal biogenesis factor 6 |
| Other gene symbols | PAF-2 PAF2 PBD4A PDB4B PXAAA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA IMP | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005778 | Peroxisomal membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IMP | biological_process |
| GO:0006625 | Protein targeting to peroxisome | IMP | biological_process |
| GO:0007031 | Peroxisome organization | IMP | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008152 | Metabolic process | IMP | biological_process |
| GO:0016561 | Protein import into peroxisome matrix, translocation | IMP | biological_process |
| GO:0016887 | ATPase activity | IMP | molecular_function |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0042623 | ATPase activity, coupled | IMP | molecular_function |
| GO:0050821 | Protein stabilization | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0486093461 | 0.2274253258 | 0.4864270209 | 0.9174041379 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1389146120 |
| GSE13712_SHEAR | Down | -2.2295410870 |
| GSE13712_STATIC | Down | -2.2310552487 |
| GSE19018 | Up | 0.0357239624 |
| GSE19899_A1 | Up | 0.1999125728 |
| GSE19899_A2 | Up | 0.3216682225 |
| PubMed_21979375_A1 | Up | 0.9502912291 |
| PubMed_21979375_A2 | Up | 1.5442969320 |
| GSE35957 | Up | 0.1975548690 |
| GSE36640 | Up | 0.4893869560 |
| GSE54402 | Up | 0.0674136508 |
| GSE9593 | Down | -0.3509984881 |
| GSE43922 | Up | 0.3312303236 |
| GSE24585 | Up | 0.0698579558 |
| GSE37065 | Down | -0.1292417097 |
| GSE28863_A1 | Up | 0.2100471352 |
| GSE28863_A2 | Up | 0.3588710013 |
| GSE28863_A3 | Down | -0.2316129909 |
| GSE28863_A4 | Down | -0.1414372762 |
| GSE48662 | Up | 0.4574344186 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-149-5p | MIMAT0000450 | MIRT045684 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051759 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051925 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17465979 | A novel role of peroxin PEX6: suppression of aging defects in mitochondria |
| 17465979 | PEX6, a peroxisome biogenesis gene, has been isolated as a multicopy suppressor of an atp2 age asymmetry mutant |
| 17465979 | Extra copies of PEX6 corrected the deficit in Atp2p in mitochondria in the mutant by improving its import kinetics, resulting in near normal mitochondrial inheritance by daughter cells |
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